What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?
Launched by GANIN FERTILITY CENTER · Nov 28, 2017
Trial Information
Current as of May 01, 2025
Unknown status
Keywords
ClinConnect Summary
Reactive oxygen species (ROS) are an integral component of sperm developmental physiology, capacitation, and function. Elevated ROS levels, from processes such as infection or inflammation, can be associated with male infertility and also decreases the overall ICSI success rates\[1\]\[2\]
Several techniques are available for measuring ROS, but only Mioxsys can measure the imbalance between production of reactive oxygen species (ROS) and activity of the antioxidant defense system in semen in terms of sORP. Mioxsys is a robust test that gives the result in a very short time, so it became app...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Diagnosed of abnormal male semen parameters such as abnormal sperm parameters according to WHO 2010 or high DNA fragmentation using TUNEL as a cause of couple infertility.
- • Abnormal sORP level on the day of ICSI.
- • Males with mild OTA (oligoteratoasthenozoospermia).
- • Female aged 18-35 years.
- • Normo responder ( \> 8 mature oocytes)
- • Male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of oocyte retrieval
- Exclusion Criteria:
- • Normal Semen fluid analysis ( WHO 2010) during the initial assessment of the male
- • Normal sORP levelat the day of ICSI
- • Leukocytospermia
- • Presence of varicocele.
- • Known genetic abnormality
- • Use of sperm donation or cryopreserved sperm
- • Use of Oocyte donation
- • Use of gestational carrier
- • Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previously known uterine infection
- • Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation
About Ganin Fertility Center
Ganin Fertility Center is a leading reproductive health institution dedicated to providing comprehensive fertility solutions and advanced reproductive technologies. With a focus on personalized patient care, the center employs a multidisciplinary approach to address various fertility challenges, utilizing state-of-the-art techniques and innovative therapies. Committed to research and clinical excellence, Ganin Fertility Center actively sponsors clinical trials aimed at enhancing treatment outcomes and advancing the field of reproductive medicine. Their team of experienced specialists collaborates closely with patients to ensure optimal care and support throughout the fertility journey.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Maadi, Cairo, Egypt
Patients applied
Trial Officials
Eman Hasanen, BSc
Principal Investigator
Ganin Fertility Center, Cairo, Egypt
Hosam Zaki, MSc, FRCOG
Study Chair
Ganin Fertility Center, Cairo, Egypt
Khaled Elqusi, BSc
Principal Investigator
Ganin Fertility Center, Cairo, Egypt
Ashok Agarwal, Ph.D
Study Director
American Center of reproductive medicine, Cleveland Clinic, Ohio, USA
Ralph Henkel, PhD
Principal Investigator
University of the Western Cape
Hanaa Elkhedr, ABB( ELD)
Principal Investigator
Ganin Fertility Center, Cairo, Egypt
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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