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Search / Trial NCT03411447

Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines

Launched by CENTRE HOSPITALIER DEPARTEMENTAL VENDEE · Jan 25, 2018

Trial Information

Current as of June 09, 2025

Terminated

Keywords

Vasoactive Drug Mechanical Ventilation Early Enteral Nutrition Intensive Care Unit Early Parenteral Nutrition Critical Care Medicine Nosocomial Infection Mortality Shock

ClinConnect Summary

A common obstacle to enteral nutrition is gastrointestinal intolerance, with regurgitations potentially responsible for gastric-content aspiration. Several studies involving technetium 99m (99mTc) labeling of gastric contents have established that gastric-fluid microaspiration is common in critically ill patients receiving both endotracheal ventilation and enteral nutrition. However, to our knowledge, no studies have specifically addressed the role for enteral nutrition in the occurrence of microaspiration. The objective of this ancillary study is to compare the frequency of gastric-content...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Invasive mechanical ventilation expected to be required more than 48 hours
  • Nutrition started within 24 hours after initiation of endotracheal mechanical ventilation
  • Treatment with vasoactive drug administered via a central venous catheter
  • Age over 18 years
  • Signed information
  • Exclusion Criteria:
  • Abdominal surgery within 1 month before inclusion
  • History of esophageal, gastric, duodenal or pancreatic surgery
  • Bleeding from the esophagus, stomach or bowel

About Centre Hospitalier Departemental Vendee

The Centre Hospitalier Départemental Vendée is a prominent healthcare institution dedicated to advancing medical knowledge through rigorous clinical research. With a commitment to patient-centered care and innovative treatment approaches, the center actively sponsors clinical trials across various therapeutic areas. By collaborating with multidisciplinary teams of healthcare professionals, the institution aims to enhance clinical outcomes and contribute to the overall improvement of public health. Its strategic focus on ethical research and adherence to regulatory standards ensures that all studies are conducted with the highest level of integrity and scientific rigor.

Locations

Amiens, , France

Paris, , France

Tours, , France

Lille, , France

Annecy, , France

Colombes, , France

Patients applied

0 patients applied

Trial Officials

Jean REIGNIER, MD, PhD

Principal Investigator

CHD Vendee

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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