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Search / Trial NCT03425253

Sequential Treatment With BELKYRA® Then Juvéderm® VOLUMA™ With Lidocaine for Overall Improvement in Jawline Contour

Launched by ALLERGAN · Feb 6, 2018

Trial Information

Current as of May 02, 2025

Completed

Keywords

Lower Face Contouring

ClinConnect Summary

Participants may be treated with up to 6 treatments with Belkyra, followed by treatment with Voluma. Participants will have opportunity to participation in a skin biopsy sub-study.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Grade 2 or above on Allergan Loss of Jawline Definition Scale (ALJDS)
  • Grade 2 or 3 on reported Clinician-Rated Submental Fat Rating Scale (CR-SMFRS)
  • Stable body weight for at least 26 weeks
  • Accept the obligation to forego any treatment or behavior (e.g., unshaven facial hair; significant changes to dietary or exercise habits) during the participants participation in the study that may affect the assessments of the submental area
  • Exclusion Criteria:
  • Grade 4 on Submental Skin Laxity Grade (SMSLG)
  • Grade 4 on Allergan Jowl Fat Rating Scale (AJFRS)
  • Body mass index (BMI) \>35 kg/m\^2
  • History of, or current symptoms of dysphagia
  • History of temporary, semi-permanent or permanent facial or neck dermal filler injections below the medial canthi at any time prior to treatment, or within 52 weeks before Screening for treatment above the medial canthi
  • History of facial and/or neck plastic surgery, tissue grafting or permanent facial implants anywhere in the face or neck
  • History of any intervention (e.g., liposuction, surgery, or lipolytic agents) to treat submental fat (SMF)
  • Evidence of any cause of enlargement in the submental area other than localized SMF
  • History of mesotherapy or ablative procedures to the face and/or neck 52 weeks before Screening
  • History of skin resurfacing in the neck or submental area within 26 weeks before Screening
  • Treatment with botulinum toxin injections in the neck or submental area within 26 weeks before Screening
  • Participants on prescription topical retinoid therapy and/or topical hormone cream applied to the face, who have not been on a consistent dose regimen for at least 26 weeks before Screening and who are unable to maintain regimen for the study
  • Systemic retinoid therapy within 52 weeks before Screening
  • Current use of oral corticosteroids
  • Is on a regimen of anticoagulation therapy (eg, warfarin, clopidogrel)
  • Has current injection site inflammatory or infectious processes, abscess, an unhealed wound, or a known cancerous or precancerous lesion in chin, masseter, or submental region
  • Planned oral surgery or other dental procedures (e.g., tooth extraction, orthodontia, or implantation) within 2 weeks prior to and after VOLUMA™ treatment

About Allergan

Allergan, a global leader in pharmaceutical innovation, specializes in developing and commercializing a diverse portfolio of advanced therapeutic and aesthetic products. With a commitment to improving the health and well-being of patients, Allergan conducts rigorous clinical trials to evaluate the safety and efficacy of its therapies across various medical fields, including ophthalmology, dermatology, and neuroscience. The company is dedicated to adhering to the highest ethical standards and regulatory guidelines, ensuring that its research not only advances medical science but also meets the needs of healthcare providers and patients worldwide. Through strategic collaborations and a focus on scientific excellence, Allergan continues to drive advancements in treatment options and enhance patient care.

Locations

South Yarra, Victoria, Australia

Darlinghurst, New South Wales, Australia

East Melbourne, Victoria, Australia

Patients applied

0 patients applied

Trial Officials

Michael Silberberg

Study Director

Allergan

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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