a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics

Launched by SHANGHAI MENTAL HEALTH CENTER · Feb 6, 2018

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age from 18-65 years old, male or female
• • 2. Subjects who met DSM-IV-TR criteria for extrapyramidal symptoms
• • 3. Scored 1 (mild) on at least two SAS items or 2 (moderate) on one of the items Exclusion Criteria are considered as antipsychotic induced parkinson ; Scored at least 2 (mild) on the BARS global item are considered as antipsychotic induced akathisia
• • 4. Written informed consent provided by legal guardians or patients
• • 5. Understand and voluntarily participate in this trail
• Exclusion Criteria:
• • 1 A history of severe nervous system disease or nervous system injury 2 A history of severe or unstable heart, liver, kidney, endocrine (including thyroid function), hematological (such as those with hemorrhagic tendency) condition 3 Subjects who have an imminent risk of suicideor who can be a threat to himself others which judged by investigator 4 Substance or alcohol dependence at enrolment 5 Pregnancy or lactation or willing to pregnant during the trial 6 Low compliance to the doctor 7 Subjects who can't take drug in time according to doctors' advice 8 scored (mild) on at least two AIMS items or 3 (moderate) on one of the items are considered as tardive dyskesia Withdrawl Criteria
• • 1. An adverse sffecr or serious adverse effect occured so that the intervention needs to be stopped
• • 2. Subjects with poor compliance or who didn't take drugs for 4 days
• • 3. Obvious plan violation ,or the safety codition and symptoms of the patients are deteriorating
• • 4. scored (mild) on at least two AIMS items or 3 (moderate) on one of the items are considered as tardive dyskesia
• • 5. Researcher's decision of the withdrawl of the subjects -