Trial of Long-term Therapeutic Hypothermia for Poor-grade Aneurysmal Subarachnoid Hemorrhage

Launched by XUANWU HOSPITAL, BEIJING · Feb 15, 2018

Keywords

ClinConnect Summary

Aneurysmal subarachnoid hemorrhage (aSAH), especially poor-grade aSAH, is a medical emergency with very high morbidity and mortality rates. SAH constitutes a major public health concern in developed and developing countries. There were several clinical trials of hypothermia for aSAH conducted, however, with conflicting results.

Hypothermia therapy treatment is currently used in our department and other large neurosurgical centers across China to decrease the intracranial pressure (ICP), mitigate some of the destructive processes, and improve the functional outcome of patients with poor-gra...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 - 65 years within 72 hours after subarachnoid hemorrhage;
• • Neurosurgical clipping or coiling for aneurysm;
• • Hunt-Hess IV-V scale;
• • The intracranial pressure is more than 20 mmHg.
• Exclusion Criteria:
• • GCS of 3 with bilateral fixed and dilated pupils;
• • No spontaneous breathing or cardiac arrest at the scene of hemorrhage;
• • No consent;
• • Pregnancy.