Renal Artery Dopplers in Twin Twin Transfusion Syndrome

Launched by COLUMBIA UNIVERSITY · Feb 22, 2018

Keywords

ClinConnect Summary

TTTS, which complicates 10-15% of MCDA twin pregnancies, is characterized by a net imbalance of volume between twins, mediated through abnormal placental blood vessel anastomoses that connect the two placental circulations. Clinically, the "donor" twin develops features of anemia and hypovolemia, while the "recipient" twin shows signs of hypervolemia and hypertensive fluid overload. If untreated, the syndrome has a perinatal mortality rate as high as 80-100%. Although modern intrauterine therapies have improved the rates of fetal death, significant risks of morbidity and mortality remain ev...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • pregnant women with monochorionic / diamniotic (MCDA) twin pregnancies with and without twin-twin transfusion syndrome (TTTS)
• • greater than 14 weeks gestation
• Exclusion Criteria:
• • higher-order multiple gestation
• • sonographic evidence of a major structural fetal anomaly (exceptions to this structural fetal anomaly exclusion are acquired recipient twin cardiac changes that are known to be associated with TTTS - these cases may be considered for study inclusion)