IVM Versus Standard IVF in Infertile Patients Diagnosed With PCOS

Launched by JIE QIAO · Mar 6, 2018

Keywords

ClinConnect Summary

A single center, randomized controlled clinical trial will enroll 350 couples with PCOS undergoing their first cycle of IVF. The participation in this study will be approximately 2 years with a total of 7 visits from the cycle beginning, pregnancy to delivery. On day 2 or day 3 following the onset of menstrual bleeding, eligible patients will be allocated to two groups at a ratio of 1:1- IVM protocol, and standard IVF protocol. All participants will be randomized through stratified block randomization according to the study sites.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Infertile couples scheduled for their first IVF cycle.
• • 2. Women diagonosed with polycystic ovarian syndrome.
• • 3. Voluntary participation and informed consent obtained.
• Exclusion Criteria:
• • 1. Couple with contraindication for IVF or ICSI.
• • 2. Couples receiving donor sperm or donor eggs.
• • 3. Couples with indications or have plan to receive PGD and PGS.
• • 4. Sperm analysis diagnosed as azoospermia;
• • 5. Either male partner or female partner with an abnormal chromosome karyotype (chromosome polymorphisms was not included).
• • 6. Women who have undergone unilateral ovariectomy.