World Maternal Antifibrinolytic Trial_2
Launched by LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE · Mar 16, 2018
Trial Information
Current as of May 20, 2025
Completed
Keywords
ClinConnect Summary
Anaemia is a cause and consequence of PPH. A cohort study in Assam, India found that women with moderate or severe anaemia had a greatly increased risk of PPH. Women with moderate anaemia had a 50% increased risk, whereas those with severe anaemia had a ten-fold increased risk of PPH. Anaemic women may be more susceptible to uterine atony due to impaired oxygen transport to the uterus. Anaemic women experience worse outcomes after PPH. An international survey of 275,000 women found that severe maternal outcomes after PPH were nearly three times more common in anaemic than in non-anaemic wom...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Women with moderate or severe anaemia (haemoglobin level \<100 g/L or packed cell volume \<30%) after giving birth vaginally where the responsible clinician is substantially uncertain whether to use TXA
- Exclusion Criteria:
- • Women who are not legally adult (\<18 years) and not accompanied by a guardian
- • Women with a known allergy to tranexamic acid or its excipients
- • Women who experience postpartum haemorrhage before the umbilical cord is cut or clamped.
About London School Of Hygiene And Tropical Medicine
The London School of Hygiene and Tropical Medicine (LSHTM) is a prestigious research institution renowned for its leadership in global health and infectious disease research. Committed to advancing public health through innovative research and education, LSHTM conducts a wide array of clinical trials aimed at improving health outcomes in diverse populations. With a multidisciplinary team of experts, LSHTM leverages cutting-edge methodologies and collaborative partnerships to address pressing health challenges, particularly in low- and middle-income countries. The institution's dedication to evidence-based solutions underscores its pivotal role in shaping health policies and practices worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ibadan, , Nigeria
Karachi, , Pakistan
Dar Es Salaam, , Tanzania
Abbottabad, , Pakistan
Bahawalpur, , Pakistan
Gujrat, , Pakistan
Islamabad, , Pakistan
Islamabad, , Pakistan
Karachi, , Pakistan
Lahore, , Pakistan
Lahore, , Pakistan
Lahore, , Pakistan
Larkana, , Pakistan
Multan, , Pakistan
Quetta, , Pakistan
Rawalpindi, , Pakistan
Rawalpindi, , Pakistan
Rawalpindi, , Pakistan
Lusaka, , Zambia
Dar Es Salaam, , Tanzania
Mbeya, , Tanzania
Abuja, , Nigeria
Akure, , Nigeria
Akure, , Nigeria
Ilorin, , Nigeria
Kano, , Nigeria
Ogbomoso, , Nigeria
Oyo, , Nigeria
Abbottabad, , Pakistan
Abbottabad, , Pakistan
Arusha, , Tanzania
Dar Es Salaam, , Tanzania
Dodoma, , Tanzania
Dodoma, , Tanzania
Kibaha, , Tanzania
Kinondoni, , Tanzania
Abbottabad, , Pakistan
Karachi, , Pakistan
Lahore, , Pakistan
Lahore, , Pakistan
Lahore, , Pakistan
Lahore, , Pakistan
Larkana, , Pakistan
Lārkāna, , Pakistan
Multan, , Pakistan
Multān, , Pakistan
Multān, , Pakistan
Patients applied
Trial Officials
Ian Roberts
Study Chair
Clinical Trials Unit, London School of Hygiene and Tropical Medicine
Haleema Shakur-Still
Study Chair
Clinical Trials Unit, London School of Hygiene and Tropical Medicine
Rizwana Chaudhri
Principal Investigator
National Coordinating Investigator, Shifa Tameer-e-Millat University, Pakistan
Folasade A Bello
Principal Investigator
National Coordinating Investigator, College of Medicine, University of Ibadan, Nigeria
Bellington Vwalika
Principal Investigator
National Coordinating Investigator, University of Zambia School of Medicine, Zambia
Projestine Muganyizi
Principal Investigator
National Coordinating Investigator, Muhimbili University of Health and Allied Sciences, Tanzania
Oladapo Olayemi
Principal Investigator
National Coordinating Investigator, College of Medicine, University of Ibadan, Nigeria
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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