PeRsOnalising Treatment Of Diabetic Nephropathy:

Launched by PETER ROSSING · Apr 16, 2018

Keywords

ClinConnect Summary

Design: Cross-sectional study, with long-term register-based follow-up. Study population: 160 patients with type 1 diabetes recruited from Steno Diabetes Center Copenhagen stratified based on stage of diabetic kidney disease, and 50 healthy non-diabetic controls. Endpoints: Primary endpoint: Glycocalyx thickness, assessed as perfused boundary region. Secondary endpoints: Gut microbiome characterisation and markers of gastrointestinal inflammation, autonomic and periphery neuropathy, urine and plasma Flow Cytometry Analysis (FACS), metabolomics and proteomics in plasma and urine, and other p...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with type 1 diabetes
• • Written informed consent must be provided before participation
• • Male or female patients \>18 years of age with a diagnosis of type 1 diabetes (WHO criteria)
• * Persistent urinary albumin creatinine ratio (UACR) assessed from EPJ (Electronic Patient Journal):
• • \< 30 mg/g in 2 out of 3 consecutive samples (normoalbuminuria)
• • 30 - 299 mg/g in 2 out of 3 consecutive samples (microalbuminuria)
• • ≥ 300 mg/g in 2 out of 3 consecutive samples (macroalbuminuria) - at least 30 with concurrent eGFR \< 60 ml/min/1.73m2
• • 2. Control subjects without diabetes
• • Written informed consent must be provided before participation.
• • Male or female patients \>18 years of age without a diagnosis of diabetes (assessed by Hb1Ac, haemoglobin and creatinine)
• • Exclusion Criteria: (Both subjects with and without diabetes)
• • Non-diabetic kidney disease as indicated by medical history and/or laboratory findings
• • Renal failure (eGFR\<15 ml/min/1.73m2), dialysis or kidney transplantation
• • Change in RAAS blocking treatment during the last month
• • Treatment with antibiotics during the last 2 month
• • Pregnancy or breastfeeding (urine HCG is performed on all fertile women)
• • Patients who, in the judgement of the investigator, is incapable to participate
• • For controls: Other diseases or intake of medicine which in the judgement of the investigator could affect the results, specifically renal, cardiovascular or inflammatory/infectious diseases should be considered for exclusion