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Search / Trial NCT03531047

Refractive Corneal Cross-linking for Progressive Keratoconus

Launched by MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST · May 8, 2018

Trial Information

Current as of May 15, 2025

Completed

Keywords

Progressive Cross Linking Customised Refractive

ClinConnect Summary

Irregular astigmatism (irregular corneal shape leading to irregular focus) is a common cause of failure to achieve an adequate spectacle correction for many patients with corneal disease. For patients affected, rigid gas permeable contact lenses are the only means of visual rehabilitation. Not all patients tolerate rigid contact lens wear, and those that do are often uncomfortable and have a restricted wearing time.

Keratoconus, in which the corneal shape becomes progressively steeper and more irregular in the 2nd to 4th decades of life, is a common cause of irregular astigmatism. Disease ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients with progressive stage I - III keratoconus
  • Corrected distance visual acuity (CDVA) \< 0.00 logMAR
  • Exclusion Criteria:
  • Patients under the age of 18 years
  • Active ocular surface disease
  • Minimum corneal thickness \< 375 µm
  • Vulnerable groups
  • Pregnancy

About Moorfields Eye Hospital Nhs Foundation Trust

Moorfields Eye Hospital NHS Foundation Trust is a leading specialist eye hospital located in London, renowned for its commitment to advancing ophthalmic research and clinical care. As a prominent clinical trial sponsor, Moorfields is dedicated to improving patient outcomes through innovative research, employing cutting-edge technology and methodologies in the field of ophthalmology. The institution collaborates with a diverse range of partners, including academic institutions and industry stakeholders, to facilitate groundbreaking studies aimed at developing new treatments and therapies for various eye conditions. With a strong focus on patient safety and ethical standards, Moorfields Eye Hospital remains at the forefront of eye care, driving progress in the understanding and management of visual impairments.

Locations

London, , United Kingdom

Patients applied

0 patients applied

Trial Officials

Daniel M Gore

Principal Investigator

Moorfields Eye Hospital NHS Foundation Trust

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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