Vitamin D Supplementation to Prevent Vitamin D Deficiency for Children With Epilepsy

Launched by KING SAUD UNIVERSITY · May 23, 2018

Keywords

ClinConnect Summary

children aged 2-16 years diagnosed with idiopathic epilepsy will be randomized to receive either cholecalciferol doses (400IU vs 1000IU) with follow up at 3 and 6 months post supplementation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Children aged between 2-16 years who were diagnosed with Epilepsy and being treated with AEDs
• • 2. Followed up in the outpatient pediatric neurology clinic at King Khalid University Hospital during the period of two years.
• Exclusion Criteria:
• 1. Children with pre-existing vitamin D metabolism problems; because they are known to need different vitamin D doses and monitoring for clinical improvement:
• • Vitamin D dependent rickets
• • Malabsorption syndromes like celiac disease, inflammatory bowel disease
• • Renal disease
• • Hepatic disease
• 2. Children who are not safe to start vitamin D supplementation; because vitamin D supplementation will causes toxicity and induces nephrocalcinosis:
• • Hypercalcemia at baseline total corrected calcium \>2.5mg/dl
• • Vitamin D level \> 250 nmol/L
• • Urine calcium: creatinine ration \> 1.2 mol/mol, or \> 0.41g/g.