Hysteroscopy in Chronic Anovulation

Launched by UNIVERSITY OF SOUTH FLORIDA · Jun 1, 2018

Keywords

ClinConnect Summary

Patients with subfertility due to hormonal disorders are at increased risk of endometrial cancer and hyperplasia . Such conditions are associated with chronic anovulation, obesity and/or hyperinsulinemia. Presumably, the mechanism relates to constant, unrelenting estrogen stimulation of the endometrium, predisposing to abnormal patterns of growth. Hence, patients with long standing anovulation presenting for infertility evaluation, are often subjected to endometrial biopsy to rule out any underlying hyperplasia or malignancy.

The polycystic ovary syndrome (PCOS) is the most obvious and com...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • All consecutive reproductive age female patients (aged 15-45) presenting to IVF clinic for medically indicated endometrial biopsy for evaluation of endometrial pathology with ability to provide written informed consent.
• Sub-fertile women presenting with history of chronic anovulation and in addition meets any one of the criteria mentioned below:
• • 1. Women with ≤ 3 menstrual cycle per year.
• • 2. Women with oligomenorrhea and BMI \>30.
• • 3. Women with oligomenorrhea and endometrial thickness \>12 mm measured during transvaginal sonography -
• Exclusion Criteria:
• • 1. Patients unable to provide informed consent.
• • 2. Patients presenting to USF-IVF clinic for evaluation of infertility but endometrial biopsy is not deemed clinically relevant based on assessment by provider.
• • 3. Patients refusing participation in lieu of additional procedure.
• • 4. Patients are already known to have existing uterine abnormality diagnosed by ultrasound. -