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Search / Trial NCT03547570

Resistance Training for Patients With Hypermobility Spectrum Disorders and Shoulder Symptoms: a Feasibility Study

Launched by UNIVERSITY OF SOUTHERN DENMARK · May 23, 2018

Trial Information

Current as of May 13, 2025

Completed

Keywords

Joint Instability Hypermobility Shoulder Strength Training

ClinConnect Summary

Hypermobility Spectrum Disorders (HSD) is a recent diagnosis that covers joint hypermobility with one or more secondary symptomatic musculoskeletal manifestations. Current clinical management of this population with shoulder symptoms is a non-standardized combination of physiotherapy modalities including exercise prescription. There is evidence suggesting that progressive heavy resistance training increases muscle strength and tendon stiffness, which may be valuable for treatment of this population.

The aim of this study is to evaluate the feasibility of progressive heavy shoulder resistan...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Men and women aged 18 - 65
  • Generalized HSD (G-HSD) defined with Beighton score cut-off ≥ 5 for women up to the age of 50 years and ≥ 4 for those above 50 years and all men \[21, 22\] or historical HSD (H-HSD) if the Beighton score was 1 point below the age and sex-specific cut-off AND the five-part questionnaire (5PQ) was positive (= at least two positive items). In patients with acquired joint limitations (past surgery, wheelchair, amputations) affecting the Beighton score calculation, the assessment of GJH only included a positive 5 part-questionnaire.
  • Present with one or more secondary symptomatic musculoskeletal manifestations, defined as either musculoskeletal pain in minimum one shoulder for at least three months or recurrent joint dislocations or joint instability without a reported history of trauma defined as: a) minimum three atraumatic dislocations in same shoulder or minimum two atraumatic dislocations in two different joints (minimum one in the shoulder) occurring at different times, or b) medical confirmation of joint instability in minimum two joints (minimum one in the shoulder) not related to trauma.
  • Exclusion Criteria:
  • Clinically suspected referred pain from the cervical spine
  • Systemic rheumatic diseases (e.g. Marfans, Stickler's or Loeys Dietz syndromes)
  • Neurological diseases
  • Pregnancy or childbirth within the latest year
  • Shoulder surgery within the past year
  • Inability to speak and understand Danish.

About University Of Southern Denmark

The University of Southern Denmark (SDU) is a prominent research institution dedicated to advancing knowledge and innovation across various fields, including health sciences. As a clinical trial sponsor, SDU is committed to conducting rigorous and ethically sound research aimed at improving patient outcomes and informing clinical practices. Leveraging its multidisciplinary expertise and state-of-the-art facilities, SDU collaborates with healthcare professionals, industry partners, and regulatory bodies to develop and execute clinical trials that adhere to the highest standards of scientific integrity and compliance. Through its research initiatives, SDU seeks to contribute to the global body of medical knowledge and enhance the quality of healthcare delivery.

Locations

Middelfart, Egion Of Southern Denmark, Denmark

Esbjerg, Region Of Southern Denmark, Denmark

Odense, Region Of Southern Denmark, Denmark

Patients applied

0 patients applied

Trial Officials

Behnam Liaghat, MSc

Principal Investigator

University of Southern Denmark

Birgit Juul-Kristensen, PhD

Study Director

University of Southern Denmark

Søren T Skou, PhD

Study Chair

University of Southern Denmark, Næstved-Slagelse-Ringsted Hospitals

Karen Søgaard, PhD

Study Chair

University of Southern Denmark

Jens Søndergaard, MD, PhD

Study Chair

University of Southern Denmark

Uffe Jørgensen, MD

Study Chair

Odense University Hospital, University of Southern Denmark

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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