Resistance Training for Patients With Hypermobility Spectrum Disorders and Shoulder Symptoms: a Feasibility Study
Launched by UNIVERSITY OF SOUTHERN DENMARK · May 23, 2018
Trial Information
Current as of May 13, 2025
Completed
Keywords
ClinConnect Summary
Hypermobility Spectrum Disorders (HSD) is a recent diagnosis that covers joint hypermobility with one or more secondary symptomatic musculoskeletal manifestations. Current clinical management of this population with shoulder symptoms is a non-standardized combination of physiotherapy modalities including exercise prescription. There is evidence suggesting that progressive heavy resistance training increases muscle strength and tendon stiffness, which may be valuable for treatment of this population.
The aim of this study is to evaluate the feasibility of progressive heavy shoulder resistan...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Men and women aged 18 - 65
- • Generalized HSD (G-HSD) defined with Beighton score cut-off ≥ 5 for women up to the age of 50 years and ≥ 4 for those above 50 years and all men \[21, 22\] or historical HSD (H-HSD) if the Beighton score was 1 point below the age and sex-specific cut-off AND the five-part questionnaire (5PQ) was positive (= at least two positive items). In patients with acquired joint limitations (past surgery, wheelchair, amputations) affecting the Beighton score calculation, the assessment of GJH only included a positive 5 part-questionnaire.
- • Present with one or more secondary symptomatic musculoskeletal manifestations, defined as either musculoskeletal pain in minimum one shoulder for at least three months or recurrent joint dislocations or joint instability without a reported history of trauma defined as: a) minimum three atraumatic dislocations in same shoulder or minimum two atraumatic dislocations in two different joints (minimum one in the shoulder) occurring at different times, or b) medical confirmation of joint instability in minimum two joints (minimum one in the shoulder) not related to trauma.
- Exclusion Criteria:
- • Clinically suspected referred pain from the cervical spine
- • Systemic rheumatic diseases (e.g. Marfans, Stickler's or Loeys Dietz syndromes)
- • Neurological diseases
- • Pregnancy or childbirth within the latest year
- • Shoulder surgery within the past year
- • Inability to speak and understand Danish.
About University Of Southern Denmark
The University of Southern Denmark (SDU) is a prominent research institution dedicated to advancing knowledge and innovation across various fields, including health sciences. As a clinical trial sponsor, SDU is committed to conducting rigorous and ethically sound research aimed at improving patient outcomes and informing clinical practices. Leveraging its multidisciplinary expertise and state-of-the-art facilities, SDU collaborates with healthcare professionals, industry partners, and regulatory bodies to develop and execute clinical trials that adhere to the highest standards of scientific integrity and compliance. Through its research initiatives, SDU seeks to contribute to the global body of medical knowledge and enhance the quality of healthcare delivery.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Middelfart, Egion Of Southern Denmark, Denmark
Esbjerg, Region Of Southern Denmark, Denmark
Odense, Region Of Southern Denmark, Denmark
Patients applied
Trial Officials
Behnam Liaghat, MSc
Principal Investigator
University of Southern Denmark
Birgit Juul-Kristensen, PhD
Study Director
University of Southern Denmark
Søren T Skou, PhD
Study Chair
University of Southern Denmark, Næstved-Slagelse-Ringsted Hospitals
Karen Søgaard, PhD
Study Chair
University of Southern Denmark
Jens Søndergaard, MD, PhD
Study Chair
University of Southern Denmark
Uffe Jørgensen, MD
Study Chair
Odense University Hospital, University of Southern Denmark
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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