Magnetic Resonance Imaging in Paediatric Constipation

Launched by NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST · Jun 8, 2018

Keywords

ClinConnect Summary

One in ten children worldwide has constipation and it becomes chronic in 30% of these children, affecting their and their families' well-being. Managing these children is difficult, partly because they do not respond to laxatives and partly because their bowel problem cannot be defined. If the doctors could send the children for a quick test that indicates the time that food takes to travel through the gut (the "gut transit time"), they could use this information to help choose the best therapy, for example to decide if a patient needs surgery. The test could also be used to follow up the e...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 7 - 18 years old
• • Male or female
• • Able to give assent or have a parent able to give informed consent
• • Willing to allow their GP or consultant, if appropriate, to be notified of participation in the clinical investigation
• • Presenting with intractable constipation at secondary or tertiary care and considered for possible treatment which may include new drugs or procedures (Group1 only)
• • Healthy bowel habit and does not suffer from constipation or diarrhoea (Group 2 only)
• Exclusion Criteria:
• • Female participants who are pregnant, lactating or planning pregnancy during the course of the investigation.
• • Any history of gastrointestinal surgery such as colectomy or small bowel resection.
• • Existing ACE procedure before the first MRI scan (Group 1 only)
• • Significant renal or hepatic impairment
• • Contraindications for MRI scanning such as metallic implants and penetrating eye injury.
• • Inability to lie flat and relatively still for less than 5 minutes
• • Poor understanding of English language
• • Any other significant disease or disorder (other than intractable constipation for Group 1)
• • Participation in another research clinical investigation involving an investigational product in the past 12 weeks.

Trial Officials