Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?

Launched by RENNES UNIVERSITY HOSPITAL · Jun 15, 2018

Keywords

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Eligibility criteria

• Inclusion Criteria:
• • Age from 18 to 55 years old
• • Clinically suspected optic neuritis defined as a sudden decrease of the visual acuity and/or a damage to the field of vision and/or a defect of the colour vision and/or retro-orbital pain with a relative afferent pupillary defect (except if the optic neuropathy is bilateral or symmetrical), in the absence of a severe retinal macular pathology, and in the absence of a toxic or iatrogenic intake (ethambutol, vfend)
• • Clinical optic neuritis duration \< 15 days
• • First episode of an inflammatory ON
• • No corticosteroids in the month before
• • Indication to a corticosteroid therapy at high dose to cure the felt symptomatology
• • Retinal nerve fibre layer (RNFL) thickness upper 75 µm at initial stage
• • Isolated ON, multiple sclerosis or NMO (Neuro Myelitis Optica) - SD (Spectrum Disorder) context
• • Having signed informed consent for participating in the study
• Exclusion Criteria:
• • Contra-indication to MRI
• • Cardiac pacemaker or defibrillator implant
• • Neurosurgical clips
• • Cochlear implants
• • Intra-orbital or encephalic foreign bodies
• • Stents implanted since less than 4 weeks and osteosynthesis equipment implanted since less than 6 weeks
• • Claustrophobia
• • Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
• • Eye examination suggests a pre-existing eye abnormality that could affect the visual function (amblyopia, strong myopia...)
• • Pregnant or breastfeeding women