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Search / Trial NCT03603743

High Intensity Interval Training vs Moderate Intensity and Continuous Training in Chronic Heart Failure

Launched by CARDIOVASCULAR AND PULMONARY REHABILITATION CENTER OF SAINT ORENS · Jul 23, 2018

Trial Information

Current as of May 27, 2025

Completed

Keywords

Exercise Training Chronic Heart Failure Parasympathetic Autonomic Nervous System Cardiorespiratory Fitness Cardiac Rehabilitation

ClinConnect Summary

Before and after the Rehabilitation Program (RP), all patients underwent a 24-hour ECG recording, an echocardiography, a cardiopulmonary exercise test.

The RP consisted of 2 types of exercise training according to the randomization:

1. a short-high intensity interval exercise with passive recovery
2. a classical moderate and continuous exercise training at 60% of peak power output

The RP lasted 4 weeks.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • stable chronic heart failure with NYHA functional class from I to III
  • stable left ventricular ejection fraction (LVEF) \< 45% over at least 6 months
  • stable optimal medical therapy including a beta-blocker and an angiotensin-converting enzyme inhibitor or angiotensin receptor blockers for at least 6 weeks
  • ability to perform a maximal cardiopulmonary exercise test
  • admitted to the Rehabilitation Centre for a comprehensive Cardiovascular Rehabilitation Program
  • Exclusion Criteria:
  • any relative or absolute contraindications to exercise training according to current recommendations
  • fixed-rate pacemaker with heart rate limits set lower than exercise training target
  • major cardiovascular event or procedure within the 3 months preceding enrolment
  • chronic atrial fibrillation
  • heart failure secondary to significant uncorrected primary valve disease (except for mitral regurgitation secondary to left ventricular dysfunction)
  • heart failure secondary to congenital heart disease or obstructive cardiomyopathy.

About Cardiovascular And Pulmonary Rehabilitation Center Of Saint Orens

The Cardiovascular and Pulmonary Rehabilitation Center of Saint Orens is a leading clinical trial sponsor dedicated to advancing research in cardiovascular and pulmonary health. With a focus on innovative rehabilitation strategies and evidence-based practices, the center aims to enhance patient outcomes through rigorous clinical studies. Committed to improving the quality of life for individuals with heart and lung conditions, the center collaborates with multidisciplinary teams to explore new therapies and interventions, ensuring a comprehensive approach to patient care and rehabilitation.

Locations

Patients applied

0 patients applied

Trial Officials

Lisa Richard, MD

Principal Investigator

Clinic of Saint-Orens, Cardiovascular and Pulmonary Rehabilitation Center, Saint-Orens-de-Gameville, France

Thibaut Guiraud, PhD

Study Director

Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (INSERM), UMR-1048, Toulouse, France

Florent Besnier, PhD

Study Chair

Clinic of Saint-Orens, Cardiovascular and Pulmonary Rehabilitation Center, Saint-Orens-de-Gameville, France. / Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (INSERM), UMR-1048, Toulouse, France

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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