Comparison of Solifenacin and Mirabegron in Treatment of Overactive Bladder Symptoms in Men After TURP

Launched by BUDDHIST TZU CHI GENERAL HOSPITAL · Aug 14, 2018

Keywords

ClinConnect Summary

Introduction:

Urinary frequency urgency and urgency urinary incontinence (UUI) are commonly encountered in patients after transurethral prostatectomy (TURP) or transurethral incision of the prostate (TUIP). \[1\] Patients usually bother by these overactive bladder (OAB) symptoms. The causes of postprostatectomy OAB might be detrusor overactivity (DO) before TURP, increase afferent input due to acute inflammation after TURP, or a weak urethral sphincter which cannot hold urine at the bladder capacity. Antimuscarinics and beta-3 adrenoceptor agonist are two different classes of medication fo...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Male patients with BPH and undergo TURP or TUIP.
• • 2. Patients void smoothly after catheter removal.
• • 3. No active urinary tract infection.
• • 4. No gross hematuria or blood clot obstruction.
• • 5. Patient or his care giver can complete voiding diary and report symptoms.
• Exclusion Criteria:
• • 1. Patients have overt neurological diseases such as cerebrovascular disease, senile dementia or spinal cord injury.
• • 2. Patients have severe medical disease and completely immobile.
• • 3. Patients have PVR larger than 150ml.
• • 4. Patients do not have OAB after TURP.

Trial Officials