Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Aug 15, 2018

Keywords

ClinConnect Summary

Any adult patient with a pituitary adenoma (either non-functioning, prolactin-secreting, growth hormone secreting, gonadotropin secreting, or TSH (thyroid stimulating hormone) secreting) or cyst scheduled to undergo transsphenoidal resection will be included in the study. Patients with chronic hyponatremia will be excluded.

Patients will be randomly assigned to one of two groups:

Group 1: these patients will be treated with moderate fluid restriction (1000 ml/24 hours for patients \<100kg and 1200 ml of fluid/24 hours for \>100 kg starting on postoperative day 1. Fluid restriction will be...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Any adult patient with a pituitary adenoma or cyst (either non-functioning, prolactin-secreting, growth hormone secreting, ACTH (adrenocorticotropic hormone)-secreting, gonadotropin secreting, or TSH secreting) scheduled to undergo pituitary resection.
• Exclusion Criteria:
• • Patients with a history of chronic hyponatremia
• • Patients with a history of SIADH (syndrome of inappropriate antidiuretic hormone) , except if secondary to hypothyroidism or adrenal insufficiency, or in association with prior TSS
• • Patients with diabetes insipidus or patients receiving DDAVP
• • Patients without an intact thirst mechanism
• • Patients with CKD (chronic kidney disease) stage III, IV or V
• • Patients with untreated adrenal insufficiency or hypothyroidism
• • Patients with class III or IV heart failure