ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis

Launched by GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE · Aug 16, 2018

Keywords

ClinConnect Summary

This is a randomized, cross-over, single-blind trial. After verification of the entry criteria, eligible patients will be, based on the randomization codes, randomly assigned to undergo either capsaicin or ATP cough provocation test (the participants will inhale capasaicin or ATP incremental concentration to induce cough, meanwhile the number of coughs and adverse events will be recorded in each concentration during the first 30 seconds), followed by a washout period of 2 to 14 days (no major changes in the use of concomitant medications are allowed,especially the medcines which are not all...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Out-patients of either gender, ex- or never-smokers, aged between 18 and 60 years
• • Cough symptoms lasting for more than 8 weeks
• • Remaining free of acute upper respiratory tract infection for at least 4 weeks
• • Agreed to participate in the trial and signed informed consent.
• Exclusion Criteria:
• • Patients with serious systemic diseases (such as malignant tumors), bullae, severe uncontrolled asthma, and a history of major hemoptysis
• • Systemic antibiotic use (except for maintenance low-dose macrolides) within 4 weeks
• • Pregnancy or lactation
• • Any known history of sensitivity to ATP or capsaicin
• • Poor understanding of the test procedure
• • Diagnosed with cough variant asthma or Eosinophilic bronchitis