To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer.

Launched by TATA MEMORIAL HOSPITAL · Sep 11, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the effects of radiation treatment after surgery for patients with advanced thyroid cancer. After removing the thyroid gland, there is a chance that the cancer could come back. This trial aims to find out if using radiation therapy can help prevent the cancer from returning, as well as to monitor any side effects that might occur from the treatment.

To be eligible for this study, patients must have a specific type of thyroid cancer called differentiated thyroid cancer, and they should have had their thyroid gland completely removed. They also need to show signs of advanced disease, such as cancer spreading beyond the thyroid or remaining cancer cells after surgery. Patients must be between 18 and 75 years old and in good health overall. If participants join the study, they can expect to receive radiation therapy and regular check-ups to assess how well the treatment is working and any side effects they may experience. This trial is currently active but not recruiting new participants at this time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • A) All patients of differentiated thyroid cancer (papillary/follicular/poorly differentiated/) who have undergone total/completion thyroidectomy at our institute and having at least two of the following features (listed below) intra-operatively and/or on histopathology
• • 1. Gross extrathyroidal spread into soft tissues of the neck, trachea, esophagus, recurrent laryngeal nerve (constituting stage T4a)
• • 2. R1/ shave resections (minimal residual disease)
• • 3. R2 resections (gross residual disease)
• • 4. Multiple lymph nodes positive(\>2) with perinodal extension at level VI B) Normal baseline haematological and biochemical parameters.
• Exclusion Criteria:
• • 1. Anaplastic or medullary thyroid cancer
• • 2. Previous history of radiation
• • 3. Pregnancy
• • 4. \< 18 years Patient unwilling to participate in the study.