Effect of LMWH on Pregnancy Outcome in Women With Multiple Failures of IVF-ET

Launched by SHENZHEN ZHONGSHAN UROLOGY HOSPITAL · Oct 8, 2018

Keywords

ClinConnect Summary

Implantation failure seems to be inevitable in some couples undergoing IVF-ET treatment, despite transferred with high-quality embryos. There are several factors, including coagulation, are supposed to contribute to the implantation failure. Several groups reported that inherited and acquired coagulation is highly prevalent in women with recurrent implantation failure (RIF). Besides, women undergoing assisted reproduction are more likely to expose to thrombotic risks because high-dose exogenous gonadotrophins are given to harvest more oocytes for the fertilization. Given the risk of thrombo...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • ≥2 consecutive IVF/ICSI-ET without clinical pregnancy
• • ≥2 oocytes retrieval cycles
• • 19\<BMI≤25
• • Normal ovarian reserve ( AMH\> 1, FSH \<10 )
• • Willing and able to sign the informed consent.
• Exclusion Criteria:
• • Uterine abnormalities confirmed by hysterosalpingography or hysteroscopy
• • Parental chromosomal abnormalities
• • PCOS
• • Anti-phospholipid Syndrome
• • Endocrine disorder
• • Endometriosis
• • Hydrosalpinx
• • Chronic disease (liver, renal, thyroid, and thrombocytopenia)
• • Regular anticoagulation or antiplatelet treatment
• • Patients who had contraindication for unfractionated heparin therapy
• • History of tuberculosis, HIV, HBV, HCV or tests indicating carriage of HBV or HCV, or positive interferon-gamma release assay in any of the couple
• • Enrollment in another clinical trial