Vitamin C Depigmenattion Versus Conventional Technique

Launched by CAIRO UNIVERSITY · Oct 23, 2018

Keywords

ClinConnect Summary

In addition to all of the previously mentioned actions of vitamin C, it was found to be involved in depigmentation due to several factors that not only depend on its direct effect on melanin and melanocytes but also due to the overall effect on the applied tissues. Melanin is one of the main reservoir for ROS, copper and calcium in the tissue cells . Once vitamin C is introduced to the target tissue, it binds efficiently to melanin due to the ROS, calcium and copper content which causes intracellular deficiency of these items and the inability of the cells to produce melanin. Calcium defici...

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Eligibility criteria

• Inclusion Criteria:
• • aged 18-50 y
• • medically free;
• • physiologic gingival hyperpigmentation related to esthetic region were selected.
• Exclusion Criteria:
• All the reasons that could provoke an inflammatory reaction were excluded such as:
• • systemic diseases (especially auto-immune diseases and chemotherapy uptake);
• • pregnant and lactating mothers;
• • usage of chlorhexidine or povidone iodine;
• • Local causes (smoking and periodontitis).