Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients

Launched by QUEEN MARY UNIVERSITY OF LONDON · Nov 7, 2018

Keywords

ClinConnect Summary

The BYPASS-CTCA trial is a single-centre, randomised controlled trial, which plans to recruit 688 patients who have had previous bypass grafts and require invasive coronary angiography over a period of 30 months.

Patients will be randomised to receive either computed tomography cardiac angiography (CTCA) prior to their invasive coronary angiogram, or invasive coronary angiography alone.

The primary endpoints will be the incidence of contrast induced nephropathy, the duration of the invasive coronary angiographic procedure and patient satisfaction. A number of secondary endpoints will also...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing invasive coronary angiogram +/- percutaneous coronary Intervention
• • 2. Previous Coronary Artery Bypass Grafting (CABG)
• • 3. Aged ≥18
• • 4. Patients able and willing to give their written informed consent.
• Exclusion Criteria:
• • 1. Subjects presenting with ST elevation myocardial infarction, cardiogenic shock (systolic blood pressure \<80 mmHg for \>30 minutes, or requiring inotropes or emergency intra aortic balloon pump for hypotension treatment) or cardiopulmonary resuscitation.
• • 2. Subjects with eGFR \<20ml/min or on renal replacement therapy.
• • 3. Current life-threatening condition other than vascular disease that may prevent a subject completing the study.
• • 4. Clinical instability including cardiogenic shock, hypotension (low blood pressure-systolic blood pressure less than 90 mmHg), sustained ventricular or atrial arrhythmia requiring intravenous medications.
• • 5. Inability to tolerate beta-blockers, including those with chronic obstructive pulmonary disease or asthma, complete heart block, second-degree atrioventricular block
• • 6. Known contrast dye allergy.
• • 7. Pregnancy or unknown pregnancy status.
• • 8. Patients considered unsuitable to participate by the research team (e.g., due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures).
• • 9. Inability or refusal to provide informed consent.
• • 10. Any inclusion criteria not met

Trial Officials