Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer
Launched by NATIONAL CANCER INSTITUTE (NCI) · Nov 9, 2018
Trial Information
Current as of June 05, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how effective a combination of targeted treatments, called ALK inhibitors, is for patients with stage IV ALK-positive non-squamous non-small cell lung cancer (NSCLC) who have already been treated. The trial looks at several medications that may help stop the growth of cancer cells by blocking certain signals that allow the cells to grow and spread. The goal is to find out whether these targeted therapies work better alone or when used together, compared to traditional chemotherapy.
To be eligible for the trial, patients must have a confirmed diagnosis of stage IV ALK-positive NSCLC and have experienced disease progression after receiving one type of second-generation ALK inhibitor. They should be willing to have a fresh biopsy if needed and meet certain health criteria, such as having stable blood counts and organ function. Participants can expect to receive either the targeted treatments or the standard chemotherapy and will be closely monitored for their response and any side effects. It's important for patients to understand that they cannot receive other cancer treatments during the trial and must follow specific guidelines regarding their health and medications.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • PRIOR TO STEP 1 REGISTRATION
- • Patients must have histologically or cytologically confirmed stage IV ALK-positive non-squamous non-small cell lung carcinoma (NSCLC) (includes M1a, M1b, M1c stage disease, American Joint Committee on Cancer \[AJCC\] 8th edition). ALK rearrangement must have been demonstrated by a Food and Drug Administration (FDA) approved assay (Vysis fluorescence in situ hybridization \[FISH\] or Ventana immunohistochemistry \[IHC\]) or by next generation sequencing (NGS)
- • Patient must be willing and able to undergo a fresh biopsy or if patient has a biopsy after progression on current tyrosine-kinase inhibitor (TKI) within 3 months of study enrollment (and has continued TKI for clinical benefit per treating physician) this tissue may be used. Must have sufficient tissue
- • Patient must have progressive disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 after one second generation ALK inhibitor, including LDK378 (ceritinib), alectinib, ensartinib, and brigatinib (may not have received more than one second-generation ALK inhibitor). Patient may have received prior crizotinib; however, the second generation ALK inhibitor received must be the last treatment given prior to study enrollment
- • Prior lorlatinib (third-generation ALK inhibitor) is not allowed
- • Prior chemotherapy is not allowed except for one prior cycle received at the time of original diagnosis of metastatic NSCLC with no evidence of disease progression following the cycle. NOTE: prior adjuvant or neoadjuvant chemotherapy is allowed if last dose was received more than 12 months prior to enrollment
- • The patient or a legally authorized representative must provide study-specific informed consent prior to Step 1 Registration
- • PRIOR TO STEP 2 REGISTRATION
- • Absolute neutrophil count (ANC) \>= 1500 cells/mm\^3 (within 28 days prior to step 2 registration)
- • Platelets \>= 100,000 cells/mm\^3 (within 28 days prior to step 2 registration)
- • Estimated creatinine clearance \>= 60 mL/min by the Cockcroft Gault formula (within 28 days prior to step 2 registration)
- • Total bilirubin =\< 1.5 x upper limit of normal (ULN) (except for patients with documented Gilbert's syndrome) (within 28 days prior to step 2 registration)
- • Aspartate aminotransferase (AST) =\< 2.5 x ULN; =\< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration)
- • Alanine aminotransferase (ALT) =\< 2.5 x ULN; =\< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration)
- • Patients with asymptomatic treated or untreated brain metastases are eligible. Treated brain metastases are eligible as long as patients have measurable disease outside the brain according to RECIST 1.1. Patients must be on a stable or decreasing dose of steroids for at least 7 days prior to step 2 registration. Anticonvulsants are allowed as long as the patient is neurologically stable and not deteriorating
- • Patients enrolled with asymptomatic brain metastases (mets) must have at least one measurable target extracranial lesion according to RECIST 1.1
- • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- • Acute effects of any prior therapy resolved to baseline severity or to Common Terminology Criteria for Adverse Events (CTCAE) grade =\< 1 (except for alopecia, hearing loss)
- • Not taking any medications that may interact with selected study medication based on stratification
- • Patients must be able to take oral medications (i.e. swallow whole tablets/capsules)
- * All females of childbearing potential must have a blood test or urine study within 14 days prior to Step 2 Registration to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:
- • Has not undergone a hysterectomy or bilateral oophorectomy; or
- • Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- • Women must not be pregnant or breast-feeding due to potential harm to the fetus or infant from ALK inhibitors and the unknown risk. Women of childbearing potential and sexually active males must agree to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study
- Exclusion Criteria:
- • Major surgery within 2 weeks of study entry. Minor surgical procedures (e.g., port insertion, pleurex catheter placement) are allowed and all wounds must not show signs of infection or draining
- • Palliative RT (\< 10 fractions) must have been completed at least 48 hours prior to study entry. Stereotactic or small field brain irradiation must have completed at least 1 week prior to study entry. Whole brain RT or other palliative RT must have been completed at least 2 weeks prior to study entry
- • Prior dose of next generation ALK inhibitor (LDK378 \[ceritinib\], alectinib, ensartinib, lorlatinib) within 5 days prior to step 2 registration. Prior dose of brigatinib within 7 days prior to step 2 registration
- • History of interstitial lung disease or interstitial fibrosis, including a history of pneumonitis, obliterative bronchiolitis, pulmonary fibrosis. Patients with a history of prior radiation pneumonitis are not excluded
- • Active inflammatory gastrointestinal disease (such as Crohns, ulcerative colitis), chronic diarrhea, symptomatic diverticular disease, or any gastrointestinal disease that would affect the absorption of oral medications or increase the risk of toxicity
- • Clinically significant cardiovascular abnormalities, as determined by the treating/registering physician, such as uncontrolled hypertension, congestive heart failure New York Heart Association (NYHA) classification of 3, unstable angina or poorly controlled arrhythmia, or myocardial infarction within 6 months
- • Active and clinically significant bacterial, fungal, or viral infection
- • Patients with active or chronic pancreatitis based on lipase elevation, symptoms, and radiographic findings
- • Other concomitant serious illness or organ system dysfunction that in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug
- • Patients must not plan to receive any other investigational agents during the course of therapy
- • Patients with active malignancy other than ALK-positive non-squamous NSCLC within the last 2 years are excluded (note: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, papillary thyroid cancer treated with curative intent, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for 2 years are eligible)
- • No chemotherapy and/or immunotherapy allowed after step 1 registration
About National Cancer Institute (Nci)
The National Cancer Institute (NCI) is a prominent component of the National Institutes of Health (NIH), dedicated to advancing cancer research and improving patient outcomes through innovative clinical trials. As a leading sponsor of cancer-related studies, NCI focuses on facilitating the development of new therapies, enhancing prevention strategies, and understanding the biology of cancer. The institute collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical trials that aim to translate scientific discoveries into effective treatments. NCI’s commitment to fostering a robust research environment supports the mission to eliminate cancer as a major health problem.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Milwaukee, Wisconsin, United States
Cleveland, Ohio, United States
Saint Louis, Missouri, United States
Philadelphia, Pennsylvania, United States
Flint, Michigan, United States
Denver, Colorado, United States
Flint, Michigan, United States
Burnsville, Minnesota, United States
Edina, Minnesota, United States
Waconia, Minnesota, United States
Boston, Massachusetts, United States
Loma Linda, California, United States
Peoria, Illinois, United States
Detroit, Michigan, United States
Bangor, Maine, United States
Oklahoma City, Oklahoma, United States
Great Falls, Montana, United States
West Palm Beach, Florida, United States
Saint Paul, Minnesota, United States
Lewistown, Pennsylvania, United States
Bozeman, Montana, United States
Kalispell, Montana, United States
Delaware, Ohio, United States
Lancaster, Ohio, United States
Sheridan, Wyoming, United States
Cincinnati, Ohio, United States
Charlottesville, Virginia, United States
Houston, Texas, United States
Dallas, Texas, United States
Lewes, Delaware, United States
Mount Vernon, Illinois, United States
Chillicothe, Ohio, United States
Gresham, Oregon, United States
Bryn Mawr, Pennsylvania, United States
Coon Rapids, Minnesota, United States
Urbana, Illinois, United States
Ann Arbor, Michigan, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Shakopee, Minnesota, United States
Willmar, Minnesota, United States
State College, Pennsylvania, United States
Council Bluffs, Iowa, United States
Dayton, Ohio, United States
Effingham, Illinois, United States
Saint Joseph, Missouri, United States
Greenville, Ohio, United States
Mount Vernon, Ohio, United States
Bethlehem, Pennsylvania, United States
Longmont, Colorado, United States
Springfield, Illinois, United States
Cincinnati, Ohio, United States
Springfield, Illinois, United States
Media, Pennsylvania, United States
Washington, District Of Columbia, United States
Honolulu, Hawaii, United States
Minneapolis, Minnesota, United States
Rochester, New York, United States
Danville, Pennsylvania, United States
Salt Lake City, Utah, United States
Scottsdale, Arizona, United States
Aurora, Colorado, United States
Jacksonville, Florida, United States
Atlanta, Georgia, United States
Honolulu, Hawaii, United States
Chicago, Illinois, United States
Indianapolis, Indiana, United States
Baltimore, Maryland, United States
Duluth, Minnesota, United States
Saint Louis, Missouri, United States
Kearney, Nebraska, United States
New York, New York, United States
Bismarck, North Dakota, United States
Fargo, North Dakota, United States
Columbus, Ohio, United States
Pittsburgh, Pennsylvania, United States
Wynnewood, Pennsylvania, United States
Newark, Delaware, United States
Aurora, Illinois, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Kettering, Ohio, United States
Tulsa, Oklahoma, United States
Allentown, Pennsylvania, United States
Federal Way, Washington, United States
Lakewood, Washington, United States
Cape Girardeau, Missouri, United States
Honolulu, Hawaii, United States
Sacramento, California, United States
Pueblo, Colorado, United States
Evanston, Illinois, United States
Fridley, Minnesota, United States
Robbinsdale, Minnesota, United States
Saint Louis Park, Minnesota, United States
Saint Louis, Missouri, United States
Omaha, Nebraska, United States
Memphis, Tennessee, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
Fort Lauderdale, Florida, United States
Oakland, California, United States
Sioux Falls, South Dakota, United States
Dallas, Texas, United States
Detroit, Michigan, United States
Rochester, Minnesota, United States
Saint Louis, Missouri, United States
Marshfield, Wisconsin, United States
Honolulu, Hawaii, United States
Newark, Ohio, United States
Decatur, Illinois, United States
Ottawa, Illinois, United States
Peoria, Illinois, United States
Helena, Montana, United States
Galesburg, Illinois, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Jackson, Michigan, United States
Lansing, Michigan, United States
Warren, Michigan, United States
Brainerd, Minnesota, United States
Duluth, Minnesota, United States
Duluth, Minnesota, United States
Lincoln, Nebraska, United States
Papillion, Nebraska, United States
Omaha, Nebraska, United States
Cape Girardeau, Missouri, United States
Peru, Illinois, United States
Des Moines, Iowa, United States
Pontiac, Michigan, United States
Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Stillwater, Minnesota, United States
Great Falls, Montana, United States
Findlay, Ohio, United States
Hazleton, Pennsylvania, United States
Wilkes Barre, Pennsylvania, United States
Scranton, Pennsylvania, United States
Chattanooga, Tennessee, United States
Bremerton, Washington, United States
Paoli, Pennsylvania, United States
Atlanta, Georgia, United States
Rohnert Park, California, United States
Sacramento, California, United States
Fremont, California, United States
Los Angeles, California, United States
Redwood City, California, United States
Richmond, California, United States
Roseville, California, United States
Sacramento, California, United States
San Francisco, California, United States
San Jose, California, United States
San Leandro, California, United States
San Rafael, California, United States
Santa Clara, California, United States
Santa Rosa, California, United States
South San Francisco, California, United States
Stockton, California, United States
Vallejo, California, United States
Walnut Creek, California, United States
Seaford, Delaware, United States
Atlanta, Georgia, United States
Lawrenceville, Georgia, United States
'Aiea, Hawaii, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Galesburg, Illinois, United States
Richmond, Indiana, United States
Ames, Iowa, United States
Saginaw, Michigan, United States
Bemidji, Minnesota, United States
Woodbury, Minnesota, United States
Joplin, Missouri, United States
Springfield, Missouri, United States
Springfield, Missouri, United States
Billings, Montana, United States
Missoula, Montana, United States
Kinston, North Carolina, United States
Boardman, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Dayton, Ohio, United States
Franklin, Ohio, United States
Troy, Ohio, United States
Warren, Ohio, United States
Youngstown, Ohio, United States
Portland, Oregon, United States
East Stroudsburg, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Tacoma, Washington, United States
Minocqua, Wisconsin, United States
Oconomowoc, Wisconsin, United States
Rice Lake, Wisconsin, United States
Waukesha, Wisconsin, United States
Weston, Wisconsin, United States
Kettering, Ohio, United States
San Diego, California, United States
Colorado Springs, Colorado, United States
Lakewood, Colorado, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Marietta, Ohio, United States
Newark, Ohio, United States
Springfield, Ohio, United States
Westerville, Ohio, United States
Zanesville, Ohio, United States
Livonia, Michigan, United States
Mansfield, Ohio, United States
Bremerton, Washington, United States
Littleton, Colorado, United States
New Ulm, Minnesota, United States
Honolulu, Hawaii, United States
Louisville, Kentucky, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Boise, Idaho, United States
Baltimore, Maryland, United States
Fargo, North Dakota, United States
Parker, Colorado, United States
La Jolla, California, United States
Joplin, Missouri, United States
Atlanta, Georgia, United States
Grand Island, Nebraska, United States
Fort Smith, Arkansas, United States
Colorado Springs, Colorado, United States
Post Falls, Idaho, United States
Bloomington, Illinois, United States
Pekin, Illinois, United States
Fergus Falls, Minnesota, United States
Branson, Missouri, United States
Saint Louis, Missouri, United States
Harrisburg, Pennsylvania, United States
Poulsbo, Washington, United States
Mckeesport, Pennsylvania, United States
Hot Springs, Arkansas, United States
Vacaville, California, United States
Jefferson City, Missouri, United States
Saint Louis, Missouri, United States
Omaha, Nebraska, United States
Oklahoma City, Oklahoma, United States
Bryan, Texas, United States
Dearborn, Michigan, United States
Anaheim, California, United States
Antioch, California, United States
Baldwin Park, California, United States
Bellflower, California, United States
Fontana, California, United States
Fresno, California, United States
Harbor City, California, United States
Irvine, California, United States
Los Angeles, California, United States
Modesto, California, United States
Oakland, California, United States
Panorama City, California, United States
Rancho Cordova, California, United States
Riverside, California, United States
Roseville, California, United States
San Diego, California, United States
San Marcos, California, United States
South San Francisco, California, United States
Woodland Hills, California, United States
Atlanta, Georgia, United States
Honolulu, Hawaii, United States
Lihue, Hawaii, United States
Rolla, Missouri, United States
Rolla, Missouri, United States
Fargo, North Dakota, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Portsmouth, Ohio, United States
Burien, Washington, United States
Vancouver, Washington, United States
New Richmond, Wisconsin, United States
Urbana, Illinois, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Columbus, Ohio, United States
Delaware, Ohio, United States
Longmont, Colorado, United States
Springfield, Ohio, United States
Saint Peters, Missouri, United States
Pittsburgh, Pennsylvania, United States
Great Falls, Montana, United States
Newark, Delaware, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Wilmington, Delaware, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Emmett, Idaho, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Sandpoint, Idaho, United States
Clive, Iowa, United States
West Des Moines, Iowa, United States
Brighton, Michigan, United States
Canton, Michigan, United States
Caro, Michigan, United States
Chelsea, Michigan, United States
Clarkston, Michigan, United States
Clarkston, Michigan, United States
East China Township, Michigan, United States
Flint, Michigan, United States
Flint, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Livonia, Michigan, United States
Macomb, Michigan, United States
Macomb, Michigan, United States
Marlette, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Rochester Hills, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
West Branch, Michigan, United States
Ypsilanti, Michigan, United States
Minneapolis, Minnesota, United States
Anaconda, Montana, United States
Centerville, Ohio, United States
Dublin, Ohio, United States
Grove City, Ohio, United States
Marion, Ohio, United States
West Chester, Ohio, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
Lewisburg, Pennsylvania, United States
Cody, Wyoming, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Durango, Colorado, United States
Golden, Colorado, United States
Lakewood, Colorado, United States
Parker, Colorado, United States
Pueblo, Colorado, United States
Thornton, Colorado, United States
Creston, Iowa, United States
Bardstown, Kentucky, United States
Corbin, Kentucky, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Shepherdsville, Kentucky, United States
Kearney, Nebraska, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Hixson, Tennessee, United States
Ooltewah, Tennessee, United States
Enumclaw, Washington, United States
Tacoma, Washington, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Danville, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
O'fallon, Illinois, United States
Swansea, Illinois, United States
Yorkville, Illinois, United States
Louisville, Kentucky, United States
Brighton, Michigan, United States
Brownstown, Michigan, United States
Canton, Michigan, United States
Chelsea, Michigan, United States
Clinton Township, Michigan, United States
Novi, Michigan, United States
West Bloomfield, Michigan, United States
Ypsilanti, Michigan, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Bonne Terre, Missouri, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Omaha, Nebraska, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Kettering, Ohio, United States
Troy, Ohio, United States
Glenview, Illinois, United States
Highland Park, Illinois, United States
Ames, Iowa, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Pottsville, Pennsylvania, United States
Dublin, California, United States
El Segundo, California, United States
Fresno, California, United States
Sacramento, California, United States
San Rafael, California, United States
Monticello, Minnesota, United States
Southhaven, Mississippi, United States
Creve Coeur, Missouri, United States
Saint Louis, Missouri, United States
Kenansville, North Carolina, United States
Richlands, North Carolina, United States
Eau Claire, Wisconsin, United States
Honolulu, Hawaii, United States
Philadelphia, Pennsylvania, United States
London, Kentucky, United States
'Aiea, Hawaii, United States
Mukwonago, Wisconsin, United States
'Aiea, Hawaii, United States
Waukesha, Wisconsin, United States
Ontario, California, United States
Ashland, Wisconsin, United States
Gahanna, Ohio, United States
Selinsgrove, Pennsylvania, United States
Phoenix, Arizona, United States
Pittsburgh, Pennsylvania, United States
San Luis Obispo, California, United States
Santa Maria, California, United States
Tawas City, Michigan, United States
Brewer, Maine, United States
Sacramento, California, United States
New York, New York, United States
Tulsa, Oklahoma, United States
Beavercreek, Ohio, United States
Stevens Point, Wisconsin, United States
Johns Creek, Georgia, United States
Clarkston, Michigan, United States
Farmington Hills, Michigan, United States
Troy, Michigan, United States
Arroyo Grande, California, United States
Springfield, Massachusetts, United States
Aitkin, Minnesota, United States
Deer River, Minnesota, United States
Hibbing, Minnesota, United States
Sandstone, Minnesota, United States
Virginia, Minnesota, United States
Hazleton, Pennsylvania, United States
Ashland, Wisconsin, United States
Colorado Springs, Colorado, United States
Plantation, Florida, United States
Honolulu, Hawaii, United States
Ballwin, Missouri, United States
Washington, Missouri, United States
Honolulu, Hawaii, United States
Worthington, Minnesota, United States
'Aiea, Hawaii, United States
Detroit Lakes, Minnesota, United States
Fosston, Minnesota, United States
Park Rapids, Minnesota, United States
Jamestown, North Dakota, United States
Altoona, Pennsylvania, United States
Springfield, Ohio, United States
Fargo, North Dakota, United States
Chadds Ford, Pennsylvania, United States
Dixon, Illinois, United States
Farmington, Missouri, United States
Frankford, Delaware, United States
Burnsville, Minnesota, United States
Bozeman, Montana, United States
Duluth, Georgia, United States
Snellville, Georgia, United States
Shelby, Michigan, United States
Cambridge, Minnesota, United States
Princeton, Minnesota, United States
Thief River Falls, Minnesota, United States
N. Huntingdon, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Washington, Pennsylvania, United States
Goodyear, Arizona, United States
Newnan, Georgia, United States
Macomb, Michigan, United States
Missoula, Montana, United States
Aventura, Florida, United States
Key West, Florida, United States
Lakewood Ranch, Florida, United States
Madison Heights, Michigan, United States
Boca Raton, Florida, United States
Fargo, North Dakota, United States
Fargo, North Dakota, United States
'Aiea, Hawaii, United States
Springfield, Illinois, United States
Grand Island, Nebraska, United States
Edina, Minnesota, United States
Boca Raton, Florida, United States
Palm Beach Gardens, Florida, United States
Bethel Park, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Aurora, Colorado, United States
Des Moines, Iowa, United States
Kalispell, Montana, United States
Troy, Ohio, United States
Nampa, Idaho, United States
Pontiac, Michigan, United States
Ann Arbor, Michigan, United States
Brighton, Michigan, United States
Chelsea, Michigan, United States
Danville, Illinois, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Ames, Iowa, United States
Canton, Michigan, United States
Minocqua, Wisconsin, United States
Clarkston, Michigan, United States
Farmington Hills, Michigan, United States
Madison Heights, Michigan, United States
Macomb, Michigan, United States
Sunset Hills, Missouri, United States
Clive, Iowa, United States
Lansing, Michigan, United States
Jefferson City, Missouri, United States
Pontiac, Michigan, United States
Kinston, North Carolina, United States
Silverdale, Washington, United States
Dayton, Ohio, United States
Troy, Michigan, United States
Sandpoint, Idaho, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
Kenansville, North Carolina, United States
Richlands, North Carolina, United States
Millville, Delaware, United States
Saginaw, Michigan, United States
Tawas City, Michigan, United States
Detroit, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Flint, Michigan, United States
Warren, Michigan, United States
Kearney, Nebraska, United States
East China Township, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Harbor City, California, United States
Grosse Pointe Woods, Michigan, United States
Rochester Hills, Michigan, United States
Mount Vernon, Illinois, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Denver, Colorado, United States
Rolla, Missouri, United States
Littleton, Colorado, United States
Parker, Colorado, United States
Cape Girardeau, Missouri, United States
Kearney, Nebraska, United States
Patients applied
Trial Officials
Jessica J Lin
Principal Investigator
NRG Oncology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials