Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid

Launched by UNIVERSITY OF VALENCIA · Dec 24, 2018

Keywords

ClinConnect Summary

Material and methods Study design A case-control study was proposed. A group of periodontally healthy subjects was compared to a group of patients with periodontitis before and after scaling and root planing.

Two sites were studied in each subject with periodontitis: one affected site (with periodontitis) and one healthy site (without periodontal disease); the latter site served as a control. Thus, the study units were the healthy and pathological sites before and after SRP treatment.

The masking was triple blind, including the researcher in charge of sample collection, the laboratory tec...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. -The control group included:
• • 10 periodontally healthy subjects
• • Without signs or symptoms of periodontal disease.
• 2. -The study group included:
• • 15 subjects diagnosed with mild or advanced chronic periodontitis.
• • One non-affected single-rooted tooth (healthy site)
• • Single-rooted tooth with periodontitis (periodontitis site) with the following features: with clinical attachment loss equal to or greater than 6 mm and bleeding upon probing.
• Exclusion Criteria:
• • Subjects with aggressive periodontitis
• • Systemic diseases or consumption of drugs affecting bone metabolism
• • Antibiotic, anti-inflammatory or contraceptive treatment for the last three months prior to study initiation
• • Antiplatelet therapy for the last 7 days prior to study onset
• • Primary or secondary occlusal trauma
• • Periapical or periodontal abscess in some of the teeth included in the study
• • Periodontal treatment within the last 6 months
• • Orthodontic treatment
• • Smoking
• • Pregnant or breastfeeding.