Observational Study Investigating Clinical & Anthropometric Characteristics of Children With Achondroplasia.

Launched by PFIZER · Jan 3, 2019

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Eligibility criteria

• Inclusion Criteria:
• • 1. Written informed consent is obtained from the children's parent(s) / legal guardian(s) before any study-related activity is carried out
• • 2. The child is able to provide written informed assent, where this is required according to national legislation, before any study related activity is carried out
• • 3. The child has been diagnosed as having achondroplasia documented by clinical diagnosis
• • 4. The child is between 0 years and 10 years of age, inclusive, on the date of consent / assent
• • 5. The investigator has considered the family and prospective participating child being able to comply with the study procedures
• Exclusion Criteria:
• • 1. The child has a diagnosis of hypochondroplasia or any short stature condition other than achondroplasia (eg, spondyloepiphyseal dysplasia congenital \[SEDC\], pseudoachondroplasia, trisomy 21)
• • 2. The child has any medical condition that may impact growth or where the treatment is known to impact growth, such as but not limited to hypothyroidism or hyperthyroidism, insulin-requiring diabetes mellitus, autoimmune inflammatory disease (including celiac disease, systemic lupus erythematosus \[SLE\], juvenile dermatomyositis, scleroderma, and others), autonomic neuropathy, or inflammatory bowel disease
• • 3. Treatment in the previous 12 months prior to consent and assent with growth hormone, insulin-like growth factor 1 (IGF-1), anabolic steroids, or any other drug expected to affect growth velocity
• • 4. Any surgery that affects the growth plate of the long bones that is planned, or has occurred in the past 18 months
• • 5. Participation in any interventional study (investigational product or device) for treatment of achondroplasia or short stature
• • 6. Has had bone-related surgery impacting assessment of anthropometric measurements or is expected to have it during the study period. Children with previous limb-lengthening surgery may enroll if surgery occurred at least 18 months prior to the date of consent/assent and healing is complete without sequelae as determined by the investigator
• • 7. Has any condition that in the view of the investigator places the child at high risk of poor compliance with the visit schedule or of not completing the study.
• • 8. Any concurrent disease or condition that in the view of the investigator would interfere with study participation