Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1

Launched by CHILDREN'S NATIONAL RESEARCH INSTITUTE · Jan 25, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at whether Whole Body MRI (WBMRI) can help find Atypical Neurofibromas (ANF) in patients with Neurofibromatosis Type 1 (NF1), a condition that causes tumors to grow on nerves. The study involves patients who have a lot of tumors and are between the ages of 8 and 30. Participants will undergo two WBMRI scans without needing sedation, which means they won't have to be put to sleep for the procedure. To join the study, individuals must have a confirmed diagnosis of NF1 and at least one larger tumor (called a plexiform neurofibroma) that is more than 3 centimeters in size.

Eligible participants should be willing to follow the study procedures and be available throughout the study period. However, those who cannot undergo an MRI without sedation or have metal devices in their body that may interfere with the MRI will not be able to participate. Overall, this study aims to improve the way doctors can detect certain types of tumors in patients with NF1, helping to guide future treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Males or females between 8-30 years of age
• • 2. Confirmed diagnosis of NF1
• • 3. Stated willingness to comply with all study procedures and availability for the duration of the study
• • 4. Prior MRI documentation confirming \>=1 PN that is \>3cm in diameter
• Exclusion Criteria:
• • 1. Unable to undergo MRI without sedation
• • 2. Presence of metal or other devices that are contraindicated for MRI