Progression of Striatal and Extrastriatal Degeneration in PD and PSP Patients

Launched by IRCCS SAN RAFFAELE ROMA · Feb 11, 2019

Keywords

ClinConnect Summary

Gait disorder is one of the key features of Parkinson's disease (PD), often leading to loss of mobility and severe disability. Yet in the early stages of disease, examination of gait may lead to inconclusive results for differential diagnosis between PD and other parkinsonism because slow and small stepped walking is often unspecific and can be related to age, depressive mood, or to a presence of neurodegenerative atypical parkinsonism (AP) such as Progressive Supranuclear Palsy (PSP).

At the same time, emerging evidence indicates that early disturbances in cognitive processes such as atte...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of idiopathic PD by United Kingdom (UK) Brain Bank criteria and PSP according to NINDS-SPSP criteria, without other significant neurological or orthopedic problems;
• • ages of 20-80;
• • able to walk 25 feet unassisted and without any assistive device
• Exclusion Criteria:
• • History of epileptic seizures, head injury, other neurological disorders.
• • Cardiac pacemaker implantation