CD19 CAR-T Cell Therapy for Relapsed/Refractory B-cell Lymphoma and B-cell Acute Lymphoblastic Leukemia

Launched by YAN'AN AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIVERSITY · Feb 25, 2019

Keywords

ClinConnect Summary

The investigators designed an KD-019 Chimeric Antigen Receptor(CAR) with FMC63 single-chain antibody fragment (Scfv). This CAR has a CD8 hinge and transmembrane domains and a 4-1BB costimulatory domain; T cells expressing this CAR release relatively low levels of cytokines. Subjects with relapsed/refractory CD19-positive B-cell Lymphoma and B-ALL can participate if all eligibility criteria are met. Subjects receive chemotherapy prior to the infusion of KD-019 CAR-T cells. After the infusion, subjects will accept follow-up for side effects and effect of KD-019 CAR-T cells by the sponsor. Stu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients or their legal guardians voluntarily participate and sign the Informed Consent Document;
• • 2. 18 Years and older, Male and female;
• • 3. Pathologically and histologically confirmed CD19 + B cell tumors; Patients currently have no effective treatment options, such as chemotherapy or relapse after hematopoietic stem cell transplantation; Or patients voluntarily choose transfusion of anti-CD19 CAR-T cells as the first treatment program;
• B-cell tumors / lymphomas and B-cell acute lymphoblastic leukemia include the following four types:
• • 1. B-cell acute lymphoblastic leukemia;
• • 2. Indolent B-cell lymphomas;
• 3. Aggressive B-cell lymphoma; 4、 Subjects:
• • (1) Residual lesions remain after treatment; (2) Not suitable for Hematopoietic stem cell transplantation (auto/allo-HSCT); (3) Relapse after Complement receptor 1 (CR1) and unsuitable for HSCT; (4) Patients with high risk factors; (5) Relapse or no remission after hematopoietic stem cell transplantation or cell immunotherapy.
• 5、 Have measurable or evaluable tumor foci; 6、 Liver, kidney and cardiopulmonary functions meet the following requirements:
• • 1. Serum glutamic pyruvic transaminase (ALT) and serum glutamic oxaloacetic transaminase (AST) \<3 ×upper limit of normal (ULN);
• • 2. Total bilirubin ≤34.2μmol/L;
• • 3. Serum creatinine\<220μmol/L;
• • 4. Baseline oxygen saturation≥95%;
• • 5. Left ventricular ejection fraction（LVEF）≥40%. 7、 Subjects who did not receive Chemotherapy, Radiotherapy, Immunotherapy (immunosuppressive drugs) or other treatment within 4 weeks prior to enrollment; Relevant toxicity≤1 grade before enrollment (except for low toxicity such as hair loss); 8、Peripheral superficial venous blood flow is smooth, which can meet the needs of intravenous drip; 9、Clinical performance status of eastern cancer cooperation group (ECOG) score ≤2，Expected survival≥3 months;
• Exclusion Criteria:
• • 1. Pregnant (urine/blood pregnancy test positive) or lactating women;
• • 2. Planned pregnancy during treatment or within 1 year after treatment, or a male subject whose partner plans pregnancy within 1 year of their cell transfusion;
• • 3. Patients cannot guarantee effective contraception (condom or contraceptives, etc.) within 1 year after enrollment;
• • 4. Active or uncontrollable infection within four weeks prior to enrollment;
• • 5. Patients with active hepatitis B/C;
• • 6. HIV-infected patients;
• • 7. Severe autoimmune or immunodeficiency disorders;
• • 8. Patients are allergic to macromolecule drugs such as antigens or cytokines;
• • 9. Subjects participated in other clinical trials within 6 weeks before enrollment;
• • 10. Systematic use of hormones within 4 weeks prior to enrollment (except for inhaled hormones);
• • 11. Mental illness;
• • 12. Drug abuse/addiction;
• • 13. The investigators consider other conditions unsuitable for enrollment.