Treatment of Gait Disorders in Children With Dravet Syndrome
Launched by UNIVERSITEIT ANTWERPEN · Feb 25, 2019
Trial Information
Current as of April 28, 2025
Completed
Keywords
ClinConnect Summary
The problem under investigation is the reduced functional mobility of patients with Dravet syndrome resulting from a crouch gait pattern. The solution, proposed in this research project, is the development of a decision framework based upon clinical gait analysis to identify the main problems and subsequently use this knowledge to select the appropriate treatment for the observed gait disorder.
Dravet syndrome is a severe infantile onset epilepsy syndrome with a prevalence of 1/15.000 to 1/30.000. In 80% of the cases it is associated with mutations in the gene encoding the alpha-subunit of...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • diagnosed with Dravet syndrome according to the criteria of Ceulemans and Cras (2004)
- • aged minimum 3 years and maximum 25 years at inclusion
- • having minimum 1 year of walking experience
- Exclusion Criteria:
- • severe epileptic seizure (status epilepticus or tonic-clonic insult over 3 min) within the 24 hours before the assessment
- • insufficient cooperation to perform 3D gait analysis
- • comorbidities of other neurological and/or orthopedic disorders not linked to Dravet syndrome
About Universiteit Antwerpen
The University of Antwerp is a leading research institution based in Belgium, renowned for its commitment to advancing knowledge and innovation in various scientific fields. With a strong emphasis on interdisciplinary collaboration, the university actively engages in clinical trials that aim to improve healthcare outcomes and enhance understanding of complex medical conditions. The University of Antwerp's dedicated research teams leverage cutting-edge methodologies and state-of-the-art facilities to conduct rigorous studies, ensuring adherence to the highest ethical standards and regulatory requirements. Through its clinical trial initiatives, the university strives to translate research findings into practical applications that benefit patients and contribute to the broader medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Leuven, , Belgium
Antwerp, , Belgium
Antwerp, , Belgium
Patients applied
Trial Officials
Ann Hallemans, PhD
Principal Investigator
Rehabilitation Sciences and Physiotherapy, University of Antwerp
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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