Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Launched by CENTRE HOSPITALIER UNIVERSITAIRE UCLOUVAIN NAMUR · Apr 9, 2019

Keywords

ClinConnect Summary

Different techniques will be used during this study :

First, the FOT. The measurements will be performed using a Tremoflo-type (Thorasys Thoracic Medical System Inc.) device that generates an oscillating pressure waveform and measures impedance of the respiratory system and its components (resistance and reactance) as a function of frequency, as well as the respiratory system resonant frequency. Measurements will be performed during tidal breathing, the subjects breathing through the pneumotachograph of the system, with nose occluded, the cheeks supported by the hands (of the subjects or o...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of COPD confirmed by post-bronchodilator (DUOVENT HFA 4 puffs) obstructive airway obstruction (FEV1/Forced Vital Capacity \< Percentile 5) persisting after bronchodilatation
• • Former or active smoking \> 10 packs/year
• • Age \> 40 years
• • Informed consent
• Exclusion Criteria:
• * Inability to comply with bronchodilator weaning time :
• • 6 hours for short-acting bronchodilators ; 12 hours for long-acting bronchodilators ; 24 hours for very long-acting bronchodilators
• • Inability to comply with the 4 hours of smoking cessation before the measurements
• • Inability to perform respiratory function tests
• • Continuous oxygen therapy
• • Close angle glaucoma
• • History of urinary retention (only for patients not usually treated with anticholinergic bronchodilators)
• • Pregnancy
• • Acute illness contraindicating the performance of respiratory tests