Optimised MultiSite Pacing Vector Study
Launched by BARTS & THE LONDON NHS TRUST · May 2, 2019
Trial Information
Current as of May 28, 2025
Withdrawn
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Symptomatic Heart Failure (NYHA class I-IV) with QRS duration of 150ms or more with left bundle branch block and LVEF of 35% or less despite optimal medical therapy.
- • Patients above 18 years of age
- • Able to provide informed consent and willing to comply with study requirements
- • Intrinsic QRS duration ≥ 150 ms
- • Sinus (or atrial paced) rhythm with intact AV conduction (PR interval ≤250 ms)
- Exclusion Criteria:
- • Resting heart rate \> 100 bpm
- • High degree AV Block (2nd or 3rd degree AV block)
- • Documented persistent atrial arrhythmia at the moment of enrolment or patients not likely to remain in sinus (or atrial paced) rhythm for the duration of the study
- • Patients scheduled for AV node ablation to treat atrial arrhythmias
- • Recent (\< 3 months) myocardial infarction, catheter ablation, electrolyte imbalance, or any condition within the last 90 days that would contraindicate CRT programming changes in the opinion of the investigator
- • Women who are pregnant or plan to become pregnant during the study course
- • Known left ventricular thrombus
About Barts & The London Nhs Trust
Barts and The London NHS Trust is a leading healthcare organization in the United Kingdom, renowned for its commitment to delivering high-quality clinical care, research, and education. As a prominent sponsor of clinical trials, the Trust is dedicated to advancing medical knowledge and improving patient outcomes through innovative research initiatives. With a focus on patient safety and ethical standards, Barts and The London NHS Trust collaborates with multidisciplinary teams to explore cutting-edge therapies and interventions across various medical fields, ensuring that trial participants receive the highest level of care and support throughout their involvement.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, , United Kingdom
Patients applied
Trial Officials
Anthony WC Chow, MBBS BSc MD
Principal Investigator
Study Chief Investigator
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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