Effect of Valproate Versus Levetiracetam Monotherapy on Reproductive Functions in Epileptic Males
Launched by ZAGAZIG UNIVERSITY · May 14, 2019
Trial Information
Current as of April 30, 2025
Completed
Keywords
ClinConnect Summary
Background: Epilepsy is a chronic neurological disorder characterized by recurrent epileptic attacks and researches have reported that the relation between epilepsy and the reproductive dysfunction is not yet completely understood. Seizures are linked with sexual dysfunction as part of the disease pathophysiology in these patients. Through epileptic discharge, hypothalamus receives signals from hippocampus, amygdala and cerebral cortex. Hypothalamic-pituitary axis signaling changes is leading to sex hormones release including follicle stimulating hormones and luteinizing hormone changes.
H...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Ages between 18-45 years.
- • All participants had normal brain imaging (Brain CT or MRI).
- • All participants had normal thyroid functions and normal sex hormones assay.
- Exclusion Criteria:
- • participants are currently receiving hormonal replacement therapy, or any drugs that may affect reproductive functions were excluded.
- • participants with significant or progressive medical illness.
- • participants with testicular atrophy, varicocele or infectious diseases .
About Zagazig University
Zagazig University, a prominent educational and research institution located in Egypt, plays a pivotal role in advancing medical knowledge and promoting health innovations through its clinical trials. With a commitment to excellence in research, the university leverages its diverse expertise and state-of-the-art facilities to conduct rigorous clinical studies that aim to improve patient care and outcomes. By fostering collaboration among multidisciplinary teams, Zagazig University contributes significantly to the global medical community, ensuring that its clinical trials adhere to the highest ethical standards and regulatory requirements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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