Juice Plus Inflammaging and Cardiovascular Disease Prevention Study

Launched by GREEN BEAT · Jun 28, 2019

Keywords

ClinConnect Summary

Inflammation is a central component of innate (non-specific) immunity. The termination of inflammation is an active process involving cytokines and anti-inflammatory mediators like lipids and micronutrients. Inflammation acts as both, 'friend and foe'; it is an essential component of immunosurveillance and host defense, but a chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as the metabolic syndrome or cardiovascular diseases (CVD). In addition, low-grade inflammation and oxidative stress are often associated with increased body fat ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 90 male and female subjects
• • age: 50 - 80 years
• • post- or peri-menopausal
• • Smokers and non-smokers
• • BMI 25 to 40 kg/m2
• • Dietary Inflammatory Index, DII: 0 to +10
• • Fruit and vegetable intake \<4 servings/d
• • Adherence to a 6-week "wash-out" period
• • Since the intervals between blood drawings are long (6 months), a temporary intake (e.g for a few days, one or two weeks) of some excluded drugs and food supplements does not necessarily mean exclusion from the study
• Exclusion Criteria:
• • Age \<50 and \>79.9 years
• • Dietary Inflammatory Index, DII: - 0.1 to -10
• • Subjects with any kind of food allergy or histamine intolerance
• • Aversion to stop the intake of nutritional supplements and food, that could interfere with the study outcome
• • Food supplements, functional foods and dietetic products with anti-inflammatory or redox-biological relevance like omega-3 fatty acids, plant/herbal extracts/concentrates, vitamin- and mineral supplements
• • Fruit and vegetable intake \>3 servings per day
• • Hypertension, starting with grade 2 according to the classification of the European Society of Hypertension: systolic blood pressure \> 160 mmHg, diastolic blood pressure \>100 mmHg
• • Medication: any anti-inflammatory medication and medication with relevant antioxidant properties, blood pressure lowering medication, psychotropic drugs, immunosuppressives, cytostatics, anticoagulants, contraceptives, diuretics, pain medication
• • Clinically relevant infectious disease
• • Diabetes mellitus type I and type II
• • Auto-immuno diseases
• • Any stents and Coronary artery diseases (CAD)
• • Cancer patients
• • Pregnancy