Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Jul 9, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a new technique called Hybrid Argon Plasma Coagulation (h-APC) to help prevent the recurrence of certain types of colon polyps after they are removed through a procedure called Endoscopic Mucosal Resection (EMR). EMR is effective for removing polyps, but when larger polyps are removed in pieces, there is a higher chance they might come back. The h-APC method uses a special tool to carefully treat the edges of the removed polyp, which may reduce the chance of recurrence. The trial aims to see if this technique really makes a difference compared to traditional methods.

To participate in this study, patients should be aged between 65 and 74 and have certain types of non-pedunculated colon polyps that are 20 mm or larger. However, patients with invasive cancer, certain health conditions, or those who are pregnant or breastfeeding cannot join. Participants will receive the h-APC treatment after their polyps are removed, and they will be monitored for any potential side effects. Overall, this trial could help improve treatment options for patients with colorectal polyps.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All Ethnicity and race
• • Patient referred for endoscopic resection of all colorectal polyps non-pedunculated equal or greater 20 mm
• • Written informed consent
• Exclusion Criteria:
• • Patients with known (biopsy proven) invasive carcinoma in a potential study polyp
• • Previous partial EMR
• • Pedunculated polyps (as defined by Paris Classification type Ip or Isp)
• • Patients with ulcerated depressed lesions (as defined by Paris Classification type III)
• • Patients with inflammatory bowel disease
• • Patients who are receiving an emergency colonoscopy
• • Poor general health (ASA class\>3)
• • Patients with coagulopathy with an elevated INR ≥1.5, or platelets \<50
• • Poor bowel preparation (Boston bowel prep score ≤2)
• • Target sign or perforation during initial EMR
• • Need for ESD for complete resection prior to APC
• • Pregnancy and breast-feeding.