Dose Adjusted vs. Fixed Dose Unilateral Laparoscopic Ovarian Drilling in PCOS Patients

Launched by HATEM ABUHASHIM · Jul 13, 2019

Keywords

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Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of PCOS will be based on the revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS and its modification (ESHRE, 2018).
• • CCR will be considered if persistent anovulation with 150 mg CC daily for 5 days per cycle, for at least three cycles.
• • Only patients with a phenotype characterized by oligomenorrhoea/anovulation, hyperandrogenaemia and polycystic ovaries on ultrasound examination (PCOM) and a phenotype characterized by oligomenorrhoea/anovulation and PCOM will be enrolled in the study.
• • Age: 20-34 years.
• • Body mass index \< 30 kg/m2
• • Patent fallopian tubes by hysterosalpingography.
• • Normal semen analysis of husbands.
• Exclusion Criteria:
• • Age ≥ 35 years.
• • BMI ≥ 30
• • Previous history of LOD
• • PCOS phenotypes with regular menses or without PCOM ovaries on USS.
• • Other causes of infertility
• • Women with adrenal hyperplasia, thyroid disease, Cushing's syndrome, hyperprolactinemia and a tumor-related excess of androgen.