Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jul 18, 2019

Keywords

ClinConnect Summary

Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign " . Septic shock associates a macrocirculatory and a microcirculatory dysfunction. The volume expansion remains the treatment of severe sepsis at the initial phase supplemented by the use of vasopressors and / or inotropes . Nevertheless , it is essential to predict the fluid responsiveness after volemic expansion because fluid overload is associated with an increased morbidity in children . In studies , th...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Baby (\>28 days) or children \< 15 years
• • 2. Hospitalisation in paediatric intensive
• • 3. Clinico-biological table compatible with severe sepsis or septic shock (likely or documented)
• • 4. Requiring the use of invasive mechanical ventilation
• • 5. Affiliate or beneficiary of a social security
• • 6. Legal guardians Consent Form or Emergency Procedure
• Exclusion Criteria:
• • 1. Any serious hemodynamic clinical situation that would be delayed by inclusion in the protocol
• • 2. Patient with shunt heart disease
• • 3. Patient in spontaneous or non-invasive ventilation or CPAP
• • 4. Patient with a contraindication to volemic/fluid expansion (major cardiac dysfunction, acute renal failure)
• • 5. Patient with cardiac arrest upper 5 min
• • 6. ECMO
• • 7. Postcardiotomia