Driving Pressure as a Predictor of Mechanical Ventilation Weaning Time on Post-ARDS Patients in Pressure Support Ventilation.

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Sep 4, 2019

Keywords

ClinConnect Summary

Scientific justification :

As mechanical ventilation developed since the 1950s, researchers started to recognize characteristic lung disease associated with it, Nash et al giving an anatomopathological description of "Respiratory Lung" on post-mortem examination of lungs after mechanical ventilation in 1967 \[2\]. It progressively led to the concept of VILI and of the protective ventilation to minimize it, enhancing lower tidal volume and plateau pressure \[3\], controlled Driving Pressure \< 15cmH2O\[4\], neuromuscular blockade\[5\] and prone positioning\[6\]. However, these parameters ca...

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Eligibility criteria

• Inclusion Criteria:
• • Patient over 18 years old
• • Patients hospitalized in the ICU and who have suffered moderate to severe ARDS (Berlin criteria) equiped with nasogastric feeding tube allowing measures of Eadi
• Exclusion Criteria:
• • COPD or measured or suspected auto-PEEP higher than 3 cmH2O at beginning of Pressure Support
• • Admission in the ICU more than 15 days before the initiation of weaning
• • Broncho-pleural leaks
• • ECMO
• • Pregnant woman.