Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE LA GUADELOUPE · Sep 17, 2019

Keywords

ClinConnect Summary

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease (6/100 000 inhabitants) characterized by the association of Parkinson's syndrome, a paralysis of the verticality of the gaze and an alteration early balance and walking with the onset of falls during the first year of evolution of the disease. From a neuropathological point of view, it is characterized by a tauopathy with neurodegeneration within the basal ganglia, cerebellum, and midbrain (which includes the mesencephalic locomotor region-MLR).

In the Caribs this pathology is abnormally frequent (incidence over 3 tim...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Patient :
• • Patients who met the clinical criteria for PSP and Gd-PSP
• • Walking and standing alone without assistance
• • Patient or responsible third party who received information about the study and who signed the informed consent
• • French
• • Patients over 40 years
• • Clinically detectable eye movement anomaly
• Witnesses :
• • To be affiliated or beneficiary of social security scheme
• • French person
• • Major subjects, matched for age (± 3 years) and sex, showing no neurological or psychiatric disease or severe progressive disease
• • No Indication against MRI
• Exclusion Criteria:
• Patient :
• • Patient not affiliated with the social security system
• • Cognitive impairment: MMSE ≤ 20; FAB ≤ 12
• • psychiatric disorders likely to interfere with exploration; severe postural disorders
• • MRI not feasible Witnesses
• • Not affiliated or benificiary of social security scheme
• • Not a french person
• • Somebody showing neurological or psychiatric disease or severe progressive disease