The Effect of Different States of Lipid in Food on Glycaemia, Lipaemia and Insulinaemia.

Launched by SINGAPORE INSTITUTE OF FOOD AND BIOTECHNOLOGY INNOVATION · Oct 3, 2019

Keywords

ClinConnect Summary

The study will have a randomized, non-blinded, crossover design. This study will explicitly compare the effects of different forms of fat (liquid and solid) on glucose, insulin and lipid response on 20 healthy male participants between the age of 21-40 years. In addition, this study aims to test the lipidemic effects of the use of vegetable oil as a substitute in the application for making chocolate confectionery.

All potential participants will be asked to attend four testing sessions and a screening session in total. During the first screening session, participants will receive an inform...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Males
• • Healthy Asian Chinese
• • Aged between 21 - 40 years
• • ≥45kg body weight
• • Body mass index between 18.5 to 25.0 kg/m2
• • Normal blood pressure ≤140/90 mmHg
• • Fasting blood glucose \<5.6 mmol/L
• Exclusion Criteria:
• • Smoking
• • Allergic/intolerant to any of the test foods to be administered, or any of the following common food and ingredients: eggs, fish, milk, peanuts, and tree nuts, shellfish, soya, wheat, gluten, cereal, fruits, dairy products, meat, vegetable, sugar and sweetener, natural food colourings or flavourings, etc.
• • Anyone with intentional food restrictions
• • People with known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• • Having metabolic or cardiovascular diseases (such as diabetes, hypertension, heart condition, etc.), Having any other diseases involving the small intestine or the colon (e.g., irritable bowel syndrome, inflammatory bowel disease, gastric reflux) or having any liver or kidney disorders or any family history of kidney stones
• • Having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• • Taking any prescribed medication or dietary supplements which may interfere with the study measurements
• • Individuals who have any major organ dysfunction (eg. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
• • Excessive alcohol consumption: consuming ≥ 6 alcoholic drinks per week
• • Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
• • Have active Tuberculosis (TB) or currently receiving treatment for TB
• • Individuals who partake in sports at the competitive and/or endurance levels
• • A team member of the study or is an immediate family member (Immediate family defined as a spouse, parent, child, or sibling, whether biological or legally adopted