An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis

Launched by TG THERAPEUTICS, INC. · Oct 16, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the long-term safety and effectiveness of a medication called ublituximab for people with relapsing multiple sclerosis (RMS). RMS is a condition that affects the brain and spinal cord, leading to symptoms like fatigue, difficulty walking, and vision problems. The study is currently active but not recruiting new participants. To be eligible, individuals must have completed a previous study involving ublituximab and be willing to follow the study rules. They also need to be in good overall health and not have any serious medical conditions that could complicate their participation.

Participants in this trial can expect to receive ublituximab and will be closely monitored for their health and any side effects over time. It's important for participants to understand that they need to agree to use reliable birth control methods during the study and for a period after receiving the medication. Additionally, those who have experienced a recent relapse of their MS or have certain medical issues will not be able to join the study. Overall, this trial aims to provide valuable information about how well ublituximab works for managing RMS over an extended period.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Participants must meet the following criteria:
• • 1. Complete the 96-week double-blind TG1101-RMS301 (NCT03277261) or TG1101-RMS302 (NCT03277248) study or complete the final Week 208 visit of the TG1101-RMS201E (NCT03381170) study
• • 2. Investigator believes may benefit from treatment with ublituximab
• • 3. Are able and willing to provide written informed consent (e.g., before the first infusion) and to comply with the study protocol
• • 4. Female participants of child-bearing potential, and male partners must consent to use a medically acceptable method of contraception from consent, throughout the study period, and for 20 weeks after the last dose of ublituximab
• Exclusion Criteria:
• Participants who meet any of the following exclusion criteria are not to be enrolled to this study:
• 1. Any significant or uncontrolled medical condition or treatment-emergent, clinically significant laboratory abnormality such as:
• • 1. Absolute neutrophil count \< 1.5 x 10e3/µL
• • 2. Hematocrit \< 24%
• • 3. Platelet count \< 150,000 cell/mm\^3
• • 4. Hypogammaglobulinemia immunoglobulin G (IgG) \< 4.0g/L
• • 2. Active infection
• • 3. Ongoing pregnancy (female participants)
• • 4. Participants who discontinued ublituximab treatment or withdrew consent from the TG1101-RMS301 or TG1101-RMS302 study during the 96-week evaluation period or prior to completing the final Week 208 visit of the TG1101-RMS201E study
• • 5. Participants who have started any disease modifying therapy (DMT), stem cell transplantation, or participation in any other interventional clinical trial after completion of the 96-week visit in the TG1101-RMS301, TG1101-RMS302, or after completing the final Week 208 visit of the TG1101-RMS201E study
• • 6. Participants who have had a confirmed multiple sclerosis (MS) relapse within the past 30 days prior to Week 1 Day 1 (W1D1). Following a relapse, participants must be neurologically stable for at least 30 days prior to screening or W1D1 of the OLE
• • 7. Participants with unstable disease activity
• • 8. Presence of malignancy, except for surgically excised basal or squamous cell skin lesions
• • 9. Vaccination with live virus within 2 months of randomization