Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury

Launched by DAMANHOUR UNIVERSITY · Nov 5, 2019

Keywords

ClinConnect Summary

1. Ethical committee approval will be obtained from Ethics committee of Faculty of Pharmacy, Damanhour University.
2. The minimum required sample size is estimated to be 40 patients for each group.
3. Full written informed consent will be taken from all patients or their next of kin to participate in this study.
4. All patients will be subjected directly at time of enrollment to the following;

* Complete history taking and demographic data
* The potential recipient risk factors for TRALI.
* The initial cause of ICU admission and the blood products received.
* Complete physical ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult (18 - 64 years) critically ill patients diagnosed with transfusion related acute lung injury (TRALI), at the time of enrollment or maximum 6 hours before, according to the National Heart, Lung and Blood Institute (NHLBI) Working Group definitions and or the Canadian Consensus Conference criteria (29, 30) as the following criteria;
• • No evidence of ALI prior to transfusion.
• • Onset of ALI ≤ 6 hours following cessation of transfusion.
• • Hypoxemia, defined as the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) ≤ 300 mmHg or oxygen saturation ≤ 90% on room air.
• • Radiographic evidence of bilateral infiltrates.
• • No evidence of left atrial hypertension.
• Exclusion Criteria:
• • Pregnancy or breastfeeding.
• • Hypernatremia or known hypersensitivity to the study drug.
• • Parenteral nutrition (total/partial) containing vitamin C.
• • Active renal stone or history of urolithiasis.
• • Acute Kidney Injury.
• • Glucose 6 phosphate dehydrogenase deficiency, iron and copper storage diseases.
• • Immunocompromised patients (cancer or patients on immunosuppressive drugs).
• • Moribund patient not expected to survive 24 hours .
• • Home mechanical ventilation (via tracheotomy or noninvasive) except for Continuous Positive Airway Pressure/ Bilevel Positive Airway Pressure (CPAP/BIPAP) used only for sleep-disordered breathing .