The Effect of Different Prebiotics on Iron Absorption From High Dose Iron Supplements

Launched by SWISS FEDERAL INSTITUTE OF TECHNOLOGY · Dec 9, 2019

Keywords

ClinConnect Summary

Prebiotics are defined as "microbial food supplements that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacterial species already resident in the colon". Moreover, prebiotics are potential enhancers of iron absorption, via several mechanisms: a) increasing gastric residence time allowing for greater iron dissolution; b) stimulating enterocyte gene expression of proteins involved in iron absorption; c) stimulating enterocyte proliferation providing a greater surface for iron absorption; and d) stimulating SCFA production by ...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female, 18 to 45 years old
• • SF concentrations ≤ 25 µg/L
• • Normal body Mass Index (18.5-24.9 kg/m2)
• • Body weight \<70 kg
• • Signed informed consent
• Exclusion Criteria:
• • Anaemia (Hb \< 11,7g/dL)
• • Any metabolic, gastrointestinal, kidney or chronic disease such as diabetes, renal failure, hepatic dysfunction, hepatitis, hypertension, cancer or cardiovascular diseases (according to the participants own statement)
• • Continuous/long-term use of medication during the whole study (except for contraceptives),
• • Consumption of mineral and vitamin supplements within 2 weeks prior to 1st supplement administration, including pre- and/or probiotic supplements (excluding foods and beverages with life cultures such as yoghurt, raw milk cheese and kombucha)
• • Blood transfusion, blood donation or significant blood loss (accident, surgery) over the past 4 months
• • Known difficulties with blood sampling
• • Use of antibiotics over the past month
• • Known hypersensitivity to iron supplements in the given amount, GOS, or lactose
• • Women who are pregnant or breast feeding
• • Women who intend to become pregnant during the course of the study
• • Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration, such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or who are not using any other method considered sufficiently reliable by the investigator in individual cases
• • Known or suspected non-compliance, drug or alcohol (more than 2 drinks/day) abuse
• • Smokers (\> 1 cigarette per week)
• • Inability to follow the procedures of the study, e.g. due to language problems, self-reported psychological disorders, etc. of the participant
• • Enrolment of the investigator, his/her family members, employees and other dependent persons