Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients

Launched by INSTITUTE OF LIVER AND BILIARY SCIENCES, INDIA · Jan 28, 2020

Keywords

ClinConnect Summary

Reduction in muscle mass (sarcopenia) is well documented in patients with chronic liver disease (CLD)leading to increased morbidity, mortality and poor quality of life. An equilibrium is maintained between the synthesis and degradation of muscles to maintain the muscle mass. However, an imbalance between the synthesis and degradation leads to loss of muscle mass. Various factors like alteration in dietary intake, hyper-metabolism, changes in amino acid profile, decreased physical activity, endotoxemia, hyperammonemia, increased myostatin levels have been postulated in the pathogenesis of mu...

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Eligibility criteria

• Inclusion Criteria:
• • Patients with decompensated cirrhosis (CTP 7-9)
• • Adult patients Age 18-60 years
• • Patients with corrected BMI in the range \<22.9
• • Those who give consent for muscle biopsy
• • INR \<1.5 or 1.5-2.5 after correction with Vitamin K
• • Platelets \> 80000
• • All etiologies
• Exclusion Criteria:
• • Presence of overt hepatic encephalopathy
• • Patients with co-morbidities e.g. acquired immunodeficiency syndrome, HCC, Other cancer, Diabetes Mellitus, chronic kidney disease, congestive heart disease , chronic respiratory disease
• • Patients with alcohol intake in past 3 months
• • Patients with TIPS
• • Patients on steroids
• • INR \>2.5
• • Refusal to participate in the trial