Identification of Biomarkers in Ischemic Stroke - Clinical Trial

Launched by UNIVERSITY HOSPITAL, BREST · Jan 31, 2020

Keywords

ClinConnect Summary

This is a monocentric study. It's a case-control study with case being first-ever ischemic stroke and controls being healthy (stroke free) subject patients paired for age, sex and cardiovascular risk or hemorrhagic stroke paired for age and sex.

Patients are followed for one year. Blood samples will be taken at inclusion, 12h, 24h, 48h, 7d, 3m and 1y. Microvesicles samples will be taken at inclusion, 7d and 3M.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * For ischemic stroke :
• • Age \> 18-year-old
• • Ischemic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRI imaging)
• • Inclusion inferior to 6 hours from stroke onset
• • Initial NIHSS score \> 0 at the time of clinical examination
• • Patients with multimodal imaging either through MRI or CT perfusion and supra-aortic vessels and intra-cerebral vessels (Willis circle) imaging \<0
• • Procedure of signed consent in situation of emergency : consent of the patient if he has the possibility to sign or his representative if he is present
• * For hemorragic stroke :
• • Age \> 18 year-old
• • Hemorrhagic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRI imaging)
• • Inclusion inferior to 6 hours from stroke onset
• • Initial NIHSS score \> 0 at the time of clinical examination
• • Hemorrhagic patients are paired for age and sex with ischemic patients
• • Procedure of signed consent in situation of emergency : consent of the patient if he has the possibility to sign or his representative if he is present
• For healthy controls :
• • Age \> 18 year-old
• • Stroke-free standardized questionnaire
• • Initial NIHSS score = 0
• • Rankin score = 0
• • High risk cardiovascular subjects
• • Controls are paired for age, sex and cardiovascular risk measured by a score (European Heart Score) with ischemic patients
• Exclusion Criteria:
• • Not affiliated to social security
• • Patient under legal protection or deprived of liberty by a judicial or administrative decision
• • Patient whose follow-up will be impossible
• • Prior stroke
• GROUP FOR ISCHEMIC STROKE :
• • - Patients with TIA and a negative cerebral CT or MRI
• GROUP FOR HEMORRAGIC STROKE :
• • Cerebral hemorrhage related to subarachnoid hemorrhage
• • Post-traumatic hemorrhage
• • Hemorrhagic transformation in patients with ischemic stroke
• GROUP FOR HEALTHY CONTROLS :
• • - Contraindication MRI