Topical L. Reuteri in Children With Atopic Dermatitis

Launched by INNOVACION Y DESARROLLO DE ESTRATEGIAS EN SALUD · Feb 9, 2020

Keywords

ClinConnect Summary

AD if a very frequent allergic skin disorders in children. Produce a negative significant impact on quality of life and related costs. Recently the changes of skin microbiota had been related with inadequate evolution of atopic dermatitis.

L. reuteri had been identified with some effect to reduce skin inflammation and help to modulate inflammatory pathways on skin. Investigators expect using topical L. reuteri as adjuvant some improvement on skin appearance due to the mode of action previous referenced additionally to some potential changes on microbiome

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children age 1 to 8 years old
• • Atopic Dermatitis (AD) according to the criteria of Hanifin and Rajka
• • SCORAD Index 15 to 50, inclusive
• • Subjects whose parents or legal representative are willing to sign the informed consent
• • When the child is 8, he/she must also give consent to participate in the study
• Exclusion Criteria:
• • Use of phototherapy for atopic dermatitis
• • Systemic or topic corticosteroids in tthe 30 days prior to the study
• • Immunosuppressive or cytostatic drugs in the 2 months prior to the study
• • Use of probiotics in the 2 weeks prior to the study
• • Other allergic severe disease (asthma, allergic rhinitis)
• • Systemic antibiotics in the four days prior to the study
• • Fever (temperature\> 37.5 °C axillary or equivalent)
• • Pathologies associated with immunodeficiency or cancer processes
• • Dermatological diseases that may hinder the evaluation of atopic dermatitis or require the continued use of topical corticosteroids
• • Subjects for whom any of the studies products are contraindicated according to their technical specifications
• • Subjects who have participated in research studies with any products in the 3 months prior to the trial