Thyroid Dysfunction in Patients With Nephrotic Syndrome

Launched by MERNA MAKRAM · Mar 25, 2020

Keywords

ClinConnect Summary

Nephrotic syndrome (NS) is one of the most popular glomerular diseases all over the world It result in loss of various macromolecules which exist in the plasma and bound to plasma proteins. They are carried away and lost in the urine due to increase glomerular membrane permeability.The abnormalities arising as a result of persistence of generalized edema , substantial heavy proteinuria \>3,5 gm/24 h 3, hypoalbuminemia\<30 g/L and hyperlipidemia Also, nephrotic syndrome may associated with thromboembolism and increase risk of infection, vitamin D deficiency, Iron deficiency and endocrine abn...

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Eligibility criteria

• Inclusion Criteria:
• * Nephrotic syndrome defined by the following:
• • 1. Generalized edema
• • 2. Urine protein excretion \> 3,5 g/24 hours
• • 3. Urine protein to creatinine ratio \> 3,500mg/g
• • 4. Serum albumin level less than 30 g/L
• Exclusion Criteria:
• • - 1) Patients \< 18 years old 2) Patients who have Thyroid diseases, current or past history of thyroid hormone or antithyroid drug intake.
• • 3) Patients who have diabetes mellitus or autoimmune diseases as systemic lupus erythematosus and RA 4) Medications known to affect thyroid function. 5) Patients with liver cirrhosis and chronic liver disease as augmentin