Effect of Postprandial Hyperinsulinaemic Hypoglycaemia on Driving Performance.

Launched by LIA BALLY · Mar 30, 2020

Keywords

ClinConnect Summary

Despite the increasing prevalence of postprandial hyperinsulinaemic hypoglycaemia (PHH), clinical implications are still unclear. Anecdotal evidence from patients with PHH suggest a high burden for these patients due to the recurrent hypoglycaemias with possibly debilitating consequences. It is well established, that even mild hypoglycaemia (plasma glucose of 3.4mmol/l) in diabetic and non-diabetic significantly impairs cognitive-motor functioning. Of note, some of the cognitive aspects remain impaired for up to 75min, even when the hypoglycaemia is corrected. In addition to the hypoglycaem...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged ≥18 years
• • Roux-en-Y gastric bypass ≥1 year ago
• • PHH defined as postprandial plasma or sensor glucose\<3.0mmol/l according to the International Hypoglycaemia Study Group (1) and exclusion of other causes of hypoglycaemia
• • Possession of a valid Swiss driver's license. Passed driver's examination at least 3 years before study inclusion. Active driving in the last 6 months before the study.
• Exclusion Criteria:
• • Clinically relevant weight changes (≥5%) within the past 3 months
• • Incapacity to give informant consent
• • Historical or current diabetes based on HbA1c ≥6.5% without glucose-lowering treatment
• • Haemoglobin level below 11 g/dl
• • Ongoing treatment with glucose-lowering drugs, anorectic drugs, steroids or any medications known to affect gastric motility
• • Active heart, lung, liver, gastrointestinal, renal or neurological disease
• • Inability to follow study procedures
• • Pregnancy or breast-feeding