Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery

Launched by FUDAN UNIVERSITY · Apr 8, 2020

Keywords

ClinConnect Summary

Postoperative neurocognitive impairments often occur in elderly patients undergoing major surgery, including postoperative delirium(POD) characterized by an acute change in cognition with altered consciousness and impaired attention, and postoperative cognitive dysfunction(POCD) mainly manifested as reduced ability of learning and memory. POD and POCD are major complications that cause disability and distress for millions of patients annually.In 2004, there was an estimated 5-40% incidence in 7.9 million patients over 65 years who had a surgical procedure subsequently experiencing either PO...

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Eligibility criteria

• Inclusion Criteria:
• • aged 60-80 years old
• • planning to undergo non-cardiac and non-neurosurgical surgery (e.g..thoracic, orthopaedic, urologic and major abdominal surgeries) under general anesthesia
• • MMSE\>20
• • Liver and kidney function are normal
• • Patients have the ability to act in full spirit, understand and sign the informed consent, and are willing to complete the whole research process.
• Exclusion Criteria:
• • Patients with personal history of allergy to methylene blue
• • Emergency Surgery
• • Patients have 6-phospho-glucose dehydrogenase deficiency (vicia faba disease)
• • Patients have recent drug administration that may lead to drug interactions(e.g..SSRIs, SNRIs)
• • Patient with a history of major head trauma
• • Patients with a history of drug or alcohol abuse
• • Patient has serious mental or neurological disorders
• • Patients with severe language, hearing and visual impairment
• • Patients have serious medical diseases(e.g..heart failure, acute stage of myocardial infarction or respiratory failure)
• • Illiteracy
• • Patients have participated in other clinical trials in the last 3 months.