Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket

Launched by UNIVERSITY OF BAGHDAD · Apr 20, 2020

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ClinConnect Summary

Abstract:

Background: Complete removal of irritants is not possible with mechanical therapy alone. Adjunctive use of systemic administration of antibiotics results in the distribution of drug throughout the body, which can give rise to toxicity. Curcumin (diferuloylmethane), a constituent of Curcuma longa plant, which possess antioxidant, anti-inflammatory, and anti-microbial properties. The aim of the study is to determine the effect of curcumin oral gel on the anti-inflammatory chemokines (IL_8) in the gingival crevicular fluid and to compare the effects of the curcumin gel as an adjunct...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age group of 30-45 years.
• • 2. Belonging to both sexes.
• • 3. Chronic periodontitis patients.
• • 4. Probing pocket depth (PPD) 5-7 mm.
• Exclusion Criteria:
• • 1. Subjects having taken antibiotics prior to or during the trial.
• • 2. Patients on medication likely to induce gingival enlargement.
• • 3. Pregnant or lactating women.
• • 4. Smokers.
• • 5. Tobacco chewers.
• • 6. Allergy to curcumin oral gel.
• • 7. Patients with systemic disease.